Results 1 to 10 of about 1,776 (189)

Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible? [PDF]

Pharmaceuticals, 2022
Pretargeting is a promising nuclear imaging technique that allows for the usage of antibodies (Abs) with enhanced imaging contrast and reduced patient radiation burden. It is based on bioorthogonal chemistry with the tetrazine ligation—a reaction between
Sara Lopes van den Broek, Vladimir Shalgunov, Rocío García Vázquez, Natalie Beschorner, Natasha S. R. Bidesi, Maiken Nedergaard, Gitte M. Knudsen, Dag Sehlin, Stina Syvänen, Matthias M. Herth   +9 more
doaj   +7 more sources

Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET [PDF]

Molecular Imaging, 2018
Positron emission tomography (PET) imaging with biological macromolecules greatly expands the possibilities of molecular imaging. There are, however, practical aspects limiting the potential of the approach, including the dosimetric consequences of the ...
Martin G. Strebl PhD, Jane Yang BS, Lyle Isaacs PhD, Jacob M. Hooker PhD   +3 more
doaj   +5 more sources

Pretargeted Molecular Imaging and Radioimmunotherapy [PDF]

Theranostics, 2012
Pretargeting is a multi-step process that first has an unlabeled bispecific antibody (bsMAb) localize within a tumor by virtue of its anti-tumor binding site(s) before administering a small, fast-clearing radiolabeled compound that then attaches to the ...
David M. Goldenberg, Chien-Hsing Chang, Edmund A. Rossi, William J, McBride, Robert M. Sharkey
doaj   +7 more sources

Pretargeted imaging and radioimmunotherapy of cancer using antibodies and bioorthogonal chemistry [PDF]

Frontiers in Medicine, 2014
Selective delivery of radionuclides to tumors may be accomplished using a two-step approach, in which in the first step the tumor is pretargeted with an unlabeled antibody construct and in the second step the tumor is targeted with a radiolabeled small ...
Otto C. Boerman
doaj   +7 more sources

Development of Polar BODIPY-Tetrazines for Rapid Pretargeted Fluorescence Imaging [PDF]

ACS Omega
Polar BODIPY-tetrazine dyes were developed and clicked in vivo to a preaccumulated trans-cyclooctene-modified anti-TAG72 monoclonal antibody CC49 (CC49-TCO). The in vivo click performance was evaluated using an in-house developed ex vivo blocking assay.
Markus Staudt, Lars Hvass, Marius Müller, Rocío García-Vázquez, Jesper Tranekjær Jo̷rgensen, Vladimir Shalgunov, Umberto Maria Battisti, Andreas Kjær, Matthias M. Herth   +8 more
doaj   +6 more sources

The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier [PDF]

Frontiers in Nuclear Medicine, 2022
Alzheimer's disease (AD) is the most common neurodegenerative disease, with an increasing prevalence. Currently, there is no ideal diagnostic molecular imaging agent for diagnosing AD.
Sara Lopes van den Broek, Dag Sehlin, Jens V. Andersen, Blanca I. Aldana, Natalie Beschörner, Maiken Nedergaard, Gitte M. Knudsen, Gitte M. Knudsen, Stina Syvänen, Matthias M. Herth, Matthias M. Herth   +10 more
doaj   +2 more sources

Pretargeted imaging beyond the blood-brain barrier. [PDF]

RSC Med Chem, 2023
By screening a library of 18 F-labeled tetrazines, we identified tetrazines which showed high pretargeted PET imaging contrast beyond the blood–brain-barrier.
Shalgunov V, Lopes van den Broek S, Vang Andersen I, García Vázquez R, Raval NR, Palner M, Mori Y, Schäfer G, Herrmann B, Mikula H, Beschorner N, Nedergaard M, Syvänen S, Barz M, Moos Knudsen G, Battisti UM, Herth MM.   +16 more
europepmc   +7 more sources

Evaluation of [⁶⁴Cu]Cu-NOTA-PEG₇-H-Tz for Pretargeted Imaging in LS174T Xenografts—Comparison to [¹¹¹In]In-DOTA-PEG₁₁-BisPy-Tz [PDF]

Molecules, 2021
Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as
Christian B. M. Poulie, Jesper T. Jørgensen, Vladimir Shalgunov, Georgios Kougioumtzoglou, Troels Elmer Jeppesen, Andreas Kjaer, Matthias M. Herth   +6 more
doaj   +2 more sources

Pretargeted Imaging and Therapy. [PDF]

J Nucl Med, 2017
In vivo pretargeting stands as a promising approach to harnessing the exquisite tumor-targeting properties of antibodies for nuclear imaging and therapy while simultaneously skirting their pharmacokinetic limitations. The core premise of pretargeting lies in administering the targeting vector and radioisotope separately and having the 2 components ...
Altai M, Membreno R, Cook B, Tolmachev V, Zeglis BM.   +4 more
europepmc   +4 more sources

Evaluation of a ⁶⁸Ga-Labeled DOTA-Tetrazine as a PET Alternative to ¹¹¹In-SPECT Pretargeted Imaging [PDF]

Molecules, 2020
The bioorthogonal reaction between a tetrazine and strained trans-cyclooctene (TCO) has garnered success in pretargeted imaging. This reaction was first validated in nuclear imaging using an 111In-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10 ...
Patricia E. Edem, Jesper T. Jørgensen, Kamilla Nørregaard, Rafaella Rossin, Abdolreza Yazdani, John F. Valliant, Marc Robillard, Matthias M. Herth, Andreas Kjaer   +8 more
doaj   +2 more sources