Results 41 to 50 of about 1,776 (189)

Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [PDF]

, 2015
Purpose: GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificity ...
Carrasquillo, Jorge A., Chalasani, Sandhya, Cheal, Sarah M., Cheung, Nai-Kong V., Fung, Edward K., Guo, Hong-fen, Jungbluth, Achim, Larson, Steven M., Lee, Sang-gyu, O’Donoghue, Joseph, Punzalan, Blesida, Smith-Jones, Peter M., Wittrup, Karl Dane, Xu, Hong, Zanzonico, Pat B.   +14 more
core   +1 more source

Optimization of Direct Aromatic ¹⁸F-Labeling of Tetrazines

Molecules, 2022
Radiolabeling of tetrazines has gained increasing attention due to their important role in pretargeted imaging or therapy. The most commonly used radionuclide in PET imaging is fluorine-18.
Ida Vang Andersen, Rocío García-Vázquez, Umberto Maria Battisti, Matthias M. Herth   +3 more
doaj   +1 more source

Eleven-year experience with the avidin-biotin pretargeting system in glioblastoma: Toxicity, efficacy and survival [PDF]

, 2012
Background: The 3-step avidin-biotin pretargeting approach is applied in patients with recurrent glioblastoma (GBM), using biotinylated anti-tenascin monoclonal antibody as the first step of pretargeting followed by avidin and 90Ybiotin.
Baio, Silvia M., Bartolomei, Mirco, Bodei, Lisa, Broggi, Giovanni, Chinol, Marco, Cremonesi, Marta, De Cicco, Concetta, Grana, Chiara M., Pacifici, Monica, Paganelli, Giovanni, Rocca, Paola A., Severi, Stefano, Tiberini, Simone   +12 more
core   +2 more sources

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

EJNMMI Research, 2019
Background Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies.
Patricia E. Edem, Jean-Philippe Sinnes, Stefanie Pektor, Nicole Bausbacher, Raffaella Rossin, Abdolreza Yazdani, Matthias Miederer, Andreas Kjær, John F. Valliant, Marc S. Robillard, Frank Rösch, Matthias M. Herth   +11 more
doaj   +1 more source

Effect of Small-Molecule-Binding Affinity on Tumor Uptake In Vivo: A Systematic Study Using a Pretargeted Bispecific Antibody [PDF]

, 2012
Small-molecule ligands specific for tumor-associated surface receptors have wide applications in cancer diagnosis and therapy. Achieving high-affinity binding to the desired target is important for improving detection limits and for increasing ...
Frangioni, John V., Orcutt, Kelly Davis, Rhoden, John J., Ruiz-Yi, Benjamin, Wittrup, Karl Dane   +4 more
core   +1 more source

Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [Zr-89]Zr-DFO-PEG(5)-Tz [PDF]

, 2022
The recent advances in the production of engineered antibodies have facilitated the development and application of tailored, target-specific antibodies.
Airaksinen, Anu J., Beaino, Wissam, Chomet, Marion, Hippeläinen, Eero, Imlimthan, Surachet, Lang, Pauline A., Lumen, Dave, Sarparanta, Mirkka, Schreurs, Maxime, Verlaan, Mariska, Vos, Ricardo, Vugts, Danielle, Windhorst, Albert D.   +12 more
core   +1 more source

Pretargeted Imaging Beyond the Blood-Brain-Barrier

, 2022
Pretargeting is a powerful nuclear imaging strategy to achieve enhanced imaging contrast for nanomedicines. It reduces the radiation burden to healthy tissue. Pretargeting is based on bioorthogonal chemistry. The most attractive reaction for this purpose is currently the tetrazine ligation, which occurs between trans-cyclooctene (TCO) tags and ...
Vladimir Shalgunov, Sara Irence Lopes van den Broek, Ida Vang Andersen, Rocío García Vázquez, Nakul Raval, Mikael Palner, Yuki Mori, Gabriela Schäfer, Hannes Mikula, Natalie Beschorner, Maiken Nedergaard, Stina Syvänen, Matthias Barz, Gitte Moos Knudsen, Umberto Maria Battisti, Matthias Herth   +15 more
openaire   +1 more source

Bioorthogonal Diels–Alder Click Chemistry-Based Pretargeted PET Imaging Strategy for Monitoring Programmed Death-Ligand 1 Expression [PDF]

ACS Omega
Yong Huang, Zhongjing Li, Chengze Li, Zihan Zang, Qiong Wang, Size Huang, Qi Liu, Ying Liang   +7 more
doaj   +2 more sources

Improvement of Radioimmunotherapy Using Pretargeting [PDF]

, 2013
During the past two decades, considerable research has been devoted to radionuclide therapy using radiolabeled monoclonal antibodies and receptor binding agents.
Caroline Bodet-Milin, Caroline Rousseau, Eric Frampas, Françoise Kraeber-Bodéré, Jacques Barbet, Jean-Francois Chatal   +5 more
core   +1 more source

Clinical Results in Medullary Thyroid Carcinoma Suggest High Potential of Pretargeted Immuno-PET for Tumor Imaging and Theranostic Approaches

Frontiers in Medicine, 2019
Monoclonal antibody (mAb)-based therapies have experienced considerable growth in cancer management. When labeled with radionuclides, mAbs also represent promising probes for imaging or theranostic approaches.
Caroline Bodet-Milin, Caroline Bodet-Milin, Clément Bailly, Clément Bailly, Yann Touchefeu, Yann Touchefeu, Eric Frampas, Eric Frampas, Mickael Bourgeois, Mickael Bourgeois, Aurore Rauscher, Aurore Rauscher, Franck Lacoeuille, Delphine Drui, Nicolas Arlicot, David M. Goldenberg, David M. Goldenberg, Alain Faivre-Chauvet, Alain Faivre-Chauvet, Jacques Barbet, Caroline Rousseau, Caroline Rousseau, Françoise Kraeber-Bodéré, Françoise Kraeber-Bodéré, Françoise Kraeber-Bodéré   +24 more
doaj   +1 more source