Results 61 to 70 of about 1,776 (189)

Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]

, 2014
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
core   +2 more sources

Targeted Therapies for Each Subtype of Breast Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review systematically summarizes the advances in targeted therapies for the three major molecular subtypes of breast cancer (BC), highlighting key strategies, agents, and clinical progress to guide personalized treatment. HR‐positive (luminal) BC: Dominated by estrogen receptor (ER) signaling, with endocrine therapies as the cornerstone—including ...
Aiyu Liu, Puchao Peng, Yeke Zhu, Qiuwen Fei, Weiwei Liu, Shizhen Zhang   +5 more
wiley   +1 more source

Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen

Biomarker Insights, 2008
Carcinoembryonic antigen (CEA), highly expressed in many cancer types, is an important target for cancer diagnosis and therapy. Radionuclide-based imaging techniques (gamma camera, single photon emission computed tomography [SPECT] and positron emission ...
Hao Hong, Jiangtao Sun, Weibo Cai Ph.D.
doaj   +2 more sources

Effect of image registration on 3D absorbed dose calculations in 177 Lu-DOTATOC Peptide Receptor Radionuclide Therapy [PDF]

, 2018
Peptide receptor radionuclide therapy (PRRT) is an effective MRT (molecular radiotherapy) treatment, which consists of multiple administrations of a radiopharmaceutical labelled with 177Lu or 90Y.
Berenato, Salvatore, Braglia, Luca, Ferri, Valentina, Filice, Angelina, Fioroni, Federica, Grassi, Elisa, Iori, Mauro, Patterson, Nick, Spezi, Emiliano, Versari, Annibale   +9 more
core   +2 more sources

Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Yujing Tan, Cheng Zeng, Jiani Wang, Fei Ma   +3 more
wiley   +1 more source

Simulations on Nickel Target Preparation and Separation of Ni(ii)- [PDF]

, 2011
SIMULATIONS ON NICKEL TARGET PREPARATION AND SEPARATION.OF Ni(II)-Cu(II) MATRIX FORPRODUCTION OF RADIOISOTOPE64Cu64Ni (p,n) 64 and retained on the column while the nickel was kept in the form of Ni2+ 2+ 2+ and CuCl while the nickel was totally in the ...
Rahman, W. (Wira), Soenarjo, S. (Sunarhadijoso), Sriyono, S. (Sriyono), Triyanto, T. (Triyanto)   +3 more
core   +2 more sources

A pretargeting nanoplatform for imaging and enhancing anti-inflammatory drug delivery

Bioactive Materials, 2020
This work details a newly developed "sandwich" nanoplatform via neutravidin-biotin system for the detection and treatment of inflammation. First, biotinylated- and folate-conjugated optical imaging micelles targeted activated macrophages via folate/folate receptor interactions.
Min Kyung Khang, Jun Zhou, Cynthia M. Co, Shuxin Li, Liping Tang   +4 more
openaire   +3 more sources

A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry [PDF]

Journal of Nuclear Medicine, 2013
The specificity of antibodies have made immunoconjugates promising vectors for the delivery of radioisotopes to cancer cells; however, their long pharmacologic half-lives necessitate the use of radioisotopes with long physical half-lives, a combination that leads to high radiation doses to patients.
Brian M, Zeglis, Kuntal K, Sevak, Thomas, Reiner, Priya, Mohindra, Sean D, Carlin, Pat, Zanzonico, Ralph, Weissleder, Jason S, Lewis   +7 more
openaire   +2 more sources

Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies

Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.
This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley   +1 more source

Site-selective protein-modification chemistry for basic biology and drug development. [PDF]

, 2015
Nature has produced intricate machinery to covalently diversify the structure of proteins after their synthesis in the ribosome. In an attempt to mimic nature, chemists have developed a large set of reactions that enable post-expression modification of ...
A Perols, A Sachdeva, AJ Keefe, B Fierz, B-Q Shen, BM Zeglis, C Chatterjee, C Goodman, CD Spicer, CT Walsh, D Schumacher, DP Nguyen, E Arbely, EM Pelegri-O'Day, EM Sletten, F Casadio, F Li, F Tian, Filipa P. da Cruz, G Pasut, GJL Bernardes, Gonçalo J. L. Bernardes, H Cho, H Neumann, HF Gaertner, HP Hemantha, J Li, J Li, J Madrzak, J Xie, J-M Kee, JI MacDonald, JL Seitchik, JM Chalker, JM Chalker, JM Chalker, JM Gilmore, JR Junutula, JY Axup, K Lang, K Lang, K Wang, KJ Hamblett, KP Chooi, L Davis, LN Tumey, M Rashidian, M Steiner, M Yang, MD Simon, N Stephanopoulos, N Toda, Nikolaus Krall, NS Beckley, Omar Boutureira, P Agarwal, P Dawson, P Wang, PM Drake, PMSD Cal, R Huang, R Rossin, R Serwa, RM Versteegen, RP Lyon, RVJ Chari, RVJ Chari, S Arur, S Tyagi, S Virdee, S Virdee, S Zheng, SI van Kasteren, SNS Alconcel, T Burckstummer, T Schneider, TS Elliott, TW Muir, W Liu   +78 more
core   +1 more source