Results 51 to 60 of about 1,776 (189)
Efficient spectroscopic imaging by an optimized encoding of pretargeted resonances [PDF]
Magnetic Resonance in Medicine, 2016 PurposeA “relaxation‐enhanced” (RE) approach to acquire in vivo localized spectra with flat baselines and good sensitivity has been recently proposed. As RE MR spectroscopy (MRS) targets a subset of a priori known resonances, new possibilities arise to acquire spectroscopic imaging data in faster, more efficient manners.
Zhiyong Zhang +2 more
openaire +2 more sources
EJNMMI Research, 2019 Background Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti ...
Fortuné M. K. Elekonawo +6 more
doaj +1 more source
In Vivo Radionuclide Generators for Diagnostics and Therapy [PDF]
, 2016 In vivo radionuclide generators make complex combinations of physical and chemical properties available for medical diagnostics and therapy. Perhaps the best-known in vivo generator is 212Pb/212Bi, which takes advantage of the extended half-life of 212Pb
Edem, Patricia E. +4 more
core +3 more sources
Development of an oxygen-sensitive degradable peptide probe for the imaging of hypoxia-inducible factor-1-active regions in tumors. [PDF]
, 2013 [Purpose]We aimed to develop a radiolabeled peptide probe for the imaging of hypoxia-inducible factor-1 (HIF-1)-active tumors. [Procedures]We synthesized the peptide probes that contain or lack an essential sequence of the oxygen-dependent degradation of
Kizaka-Kondoh, Shinae +5 more
core +1 more source
Molecules, 2020 Fluorine-18 is the most widely used positron emission tomography (PET) radionuclide currently in clinical application, due to its optimal nuclear properties. The synthesis of 18F-labeled radiotracers often requires harsh reaction conditions, limiting the
Sofia Otaru +5 more
doaj +1 more source
Single cell imaging of Bruton's Tyrosine Kinase using an irreversible inhibitor [PDF]
, 2014 A number of Bruton's tyrosine kinase (BTK) inhibitors are currently in development, yet it has been difficult to visualize BTK expression and pharmacological inhibition in vivo in real time.
Kim, Eunha +4 more
core +1 more source
Chapter Pretargeted Theranostics [PDF]
, 2021 Personalized medicine is becoming an integral part of our healthcare system, in which theranostics play a fundamental role. Nanomedicines such as monoclonal antibodies are a commonly used targeting vector in such approaches due to their outstanding ...
B.M. Poulie, Christian +2 more
core +1 more source
Synthesis and ex vivo biodistribution of two 68Ga-labeled tetrazine tracers : comparison of pharmacokinetics [PDF]
, 2022 Peer ...
Airaksinen, Anu J. +8 more
core +1 more source
Direct imaging of glycans in Arabidopsis roots via click labeling of metabolically incorporated azido-monosaccharides [PDF]
, 2016 Background: Carbohydrates, also called glycans, play a crucial but not fully understood role in plant health and development. The non-template driven formation of glycans makes it impossible to image them in vivo with genetically encoded fluorescent tags
Dario Cramer +5 more
core +10 more sources
Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality
Chemistry – A European Journal, EarlyView.Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim +3 more
wiley +1 more source