Cancer imaging and therapy with bispecific antibody pretargeting [PDF]
Update on Cancer Therapeutics, 2007 This article reviews recent preclinical and clinical advances in the use of pretargeting methods for the radioimmunodetection and radioimmunotherapy of cancer. Whereas directly-labeled antibodies, fragments, and subfragments (minibodies and other constructs) have shown promise in both imaging and therapy applications over the past 25 years, their ...
David M, Goldenberg +4 more
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A pretargeting system for tumor PET imaging and radioimmunotherapy [PDF]
Frontiers in Pharmacology, 2015 Labeled antibodies, as well as their fragments and antibody-derived recombinant constructs, have long been proposed as general vectors to target radionuclides to tumor lesions for imaging and therapy. They have indeed shown promise in both imaging and therapeutic applications, but they have not fulfilled the original expectations of achieving ...
Françoise eKraeber-Bodéré +10 more
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Exploring In Vivo Metal Chelation as an Approach for Pretargeted PET Imaging [PDF]
ACS OmegaAishwarya Mishra +3 more
doaj +2 more sources
Pretargeted PET Imaging Using a Site-Specifically Labeled Immunoconjugate [PDF]
Bioconjugate Chemistry, 2016 In recent years, both site-specific bioconjugation techniques and bioorthogonal pretargeting strategies have emerged as exciting technologies with the potential to improve the safety and efficacy of antibody-based nuclear imaging. In the work at hand, we have combined these two approaches to create a pretargeted PET imaging strategy based on the rapid ...
Brendon E, Cook +8 more
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99Tcm-labeled Glucose Metabolism Imaging Agents Based on in Vivo Copper-free Click Chemistry
Journal of Isotopes, 2021 In order to develop an ideal 99Tcm-labeled glucose metabolism imaging agent, MAMA-conjugated azadibenzocyclooctyne derivative and four 2-azido glucose derivatives were synthesized. Two potential candidates (N3-DG-1 and N3-DG-2) were selected according to
CHEN Qingxin;CHU Taiwei
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Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and Astatine-211
Pharmaceuticals, 2023 To enhance targeting efficacy in the radioimmunotherapy of disseminated cancer, several pretargeting strategies have been developed. In pretargeted radioimmunotherapy, the tumor is pretargeted with a modified monoclonal antibody that has an affinity for ...
Chiara Timperanza +4 more
doaj +1 more source
Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging [PDF]
Bioconjugate Chemistry, 2008 Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. The reaction is high yielding, selective, and fast in aqueous media.
Neal K, Devaraj +2 more
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Recent Advances in the Development of Tetrazine Ligation Tools for Pretargeted Nuclear Imaging
Pharmaceuticals, 2022 Tetrazine ligation has gained interest as a bio-orthogonal chemistry tool within the last decade. In nuclear medicine, tetrazine ligation is currently being explored for pretargeted approaches, which have the potential to revolutionize state-of-the-art ...
Rocío García-Vázquez +2 more
doaj +1 more source
Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha [PDF]
, 2010 PURPOSE: Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant tumour progression. For the imaging of HIF-1-active tumours, we previously developed a protein, POS, which is effectively delivered to and selectively stabilized in HIF-1 ...
Hiraoka, Masahiro +10 more
core +1 more source
Pretargeting for imaging and therapy in oncological nuclear medicine [PDF]
EJNMMI Radiopharmacy and Chemistry, 2017 Oncological pretargeting has been implemented and tested in several different ways in preclinical models and clinical trials over more than 30 years. Despite highly promising results, pretargeting has not achieved market approval even though it could be considered the ultimate theranostic, combining PET imaging with short-lived positron emitters and ...
Bailly, Clément +5 more
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