Results 11 to 20 of about 1,776 (189)

Development of ¹⁸F-Labeled Bispyridyl Tetrazines for In Vivo Pretargeted PET Imaging [PDF]

Pharmaceuticals, 2022
Pretargeted PET imaging is an emerging and fast-developing method to monitor immuno-oncology strategies. Currently, tetrazine ligation is considered the most promising bioorthogonal reaction for pretargeting in vivo.
Rocío García-Vázquez, Jesper Tranekjær Jørgensen, Klas Erik Bratteby, Vladimir Shalgunov, Lars Hvass, Matthias M. Herth, Andreas Kjær, Umberto Maria Battisti   +7 more
doaj   +5 more sources

Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models [PDF]

EJNMMI Research, 2017
Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient.
Outi Keinänen, Kimberly Fung, Jacob Pourat, Vilma Jallinoja, Delphine Vivier, NagaVara Kishore Pillarsetty, Anu J. Airaksinen, Jason S. Lewis, Brian M. Zeglis, Mirkka Sarparanta   +9 more
doaj   +5 more sources

Theranostic Pretargeting Drug Delivery and Imaging Platforms in Cancer Precision Medicine [PDF]

Frontiers in Oncology, 2020
Theranostics are nano-size or molecular-level agents serving for both diagnosis and therapy. Structurally, they are drug delivery systems integrated with molecular or targeted imaging agents.
Sudath Hapuarachchige, Dmitri Artemov, Dmitri Artemov   +2 more
doaj   +3 more sources

Pretargeted PET Imaging of trans-Cyclooctene-Modified Porous Silicon Nanoparticles [PDF]

ACS Omega, 2017
Pretargeted positron emission tomography (PET) imaging based on bioorthogonal chemical reactions has proven its potential in immunoimaging. It may also have great potential in nanotheranostic applications. Here, we report the first successful pretargeted PET imaging of trans-cyclooctene-modified mesoporous silicon nanoparticles, using 18F-labeled ...
Outi Keinänen, Ermei M. Mäkilä, Rici Lindgren, Helena Virtanen, Heidi Liljenbäck, Vesa Oikonen, Mirkka Sarparanta, Carla Molthoff, Albert D. Windhorst, Anne Roivainen, Jarno J. Salonen, Anu J. Airaksinen   +11 more
doaj   +7 more sources

A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET [PDF]

EJNMMI Radiopharmacy and Chemistry, 2022
Background Pretargeted immuno-PET tumor imaging has emerged as a valuable diagnostic strategy that combines the high specificity of antibody-antigen interaction with the high signal and image resolution offered by short-lived PET isotopes, while reducing
Hugo Helbert, Emily M. Ploeg, Douwe F. Samplonius, Simon N. Blok, Ines F. Antunes, Verena I. Böhmer, Gert Luurtsema, Rudi A. J. O. Dierckx, Ben L. Feringa, Philip H. Elsinga, Wiktor Szymanski, Wijnand Helfrich   +11 more
doaj   +2 more sources

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18-labeled tetrazine [PDF]

Translational Neurodegeneration
Background Antibody-based positron emission tomography (PET) imaging holds great promise for visualizing disease-related proteins in the brain. However, its clinical utility is limited by poor antibody penetration across the blood–brain barrier (BBB) and
Sara Lopes van den Broek, Jonas Eriksson, Qiaojun Yang, Nadja M. Bucher, Eva Schlein, Lorenzo J. I. Balestri, Luke R. Odell, Dag Sehlin, Stina Syvänen   +8 more
doaj   +2 more sources

(99m)Tc-bioorthogonal click chemistry reagent for in vivo pretargeted imaging. [PDF]

Bioorg Med Chem, 2016
Metal-free click chemistry has become an important tool for pretargeted approaches in the molecular imaging field. The application of bioorthogonal click chemistry between a pretargeted trans-cyclooctene (TCO) derivatized monoclonal antibody (mAb) and a (99m)Tc-modified 1,2,4,5-tetrazine for tumor imaging was examined in vitro and in vivo.
García MF, Zhang X, Shah M, Newton-Northup J, Cabral P, Cerecetto H, Quinn T.   +6 more
europepmc   +4 more sources

Pretargeted Imaging with Gallium-68—Improving the Binding Capability by Increasing the Number of Tetrazine Motifs [PDF]

Pharmaceuticals, 2018
The inverse electron-demand Diels-Alder reaction between 1,2,4,5-tetrazine (Tz) and trans-cyclooct-2-ene (TCO) has gained increasing attraction among extensive studies on click chemistry due to its exceptionally fast reaction kinetics and high ...
Dominik Summer, Sonja Mayr, Milos Petrik, Christine Rangger, Katia Schoeler, Lisa Vieider, Barbara Matuszczak, Clemens Decristoforo   +7 more
doaj   +2 more sources

Bifunctional phage-based pretargeted imaging of human prostate carcinoma. [PDF]

Nucl Med Biol, 2009
Two-step and three-step pretargeting systems utilizing biotinylated prostate tumor-homing bacteriophage (phage) and (111)In-radiolabeled streptavidin or biotin were developed for use in cancer radioimaging. The in vivo selected prostate carcinoma-specific phage (G1) displaying up to five copies of the peptide IAGLATPGWSHWLAL was the focus of the ...
Newton-Northup JR, Figueroa SD, Quinn TP, Deutscher SL.   +3 more
europepmc   +4 more sources

Development of a 99mTc-labeled tetrazine for pretargeted SPECT imaging using an alendronic acid-based bone targeting model. [PDF]

PLoS ONE
Pretargeting, which is the separation of target accumulation and the administration of a secondary imaging agent into two sequential steps, offers the potential to improve image contrast and reduce radiation burden for nuclear imaging.
Lennart Bohrmann, Christian B M Poulie, Cristina Rodríguez-Rodríguez, Stoyan Karagiozov, Katayoun Saatchi, Matthias M Herth, Urs O Häfeli   +6 more
doaj   +4 more sources