Results 11 to 20 of about 2,392 (196)
Therapeutic Applications of Pretargeting [PDF]
Pharmaceutics, 2019 Targeted therapies, such as radioimmunotherapy (RIT), present a promising treatment option for the eradication of tumor lesions. RIT has shown promising results especially for hematologic malignancies, but the therapeutic efficacy is limited by ...
Marjolein Verhoeven +2 more
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Pretargeting of Carcinomas with the Avidin-Biotin System
The International Journal of Biological Markers, 1993 Diagnosis and experimental therapy of cancer have been performed with encouraging results using radiolabelled monoclonal antibodies. However, the high background due to non-specific uptake by normal tissue and blood is a major drawback in antibody-guided
G. Paganelli, P. Magnani, F. Fazio
doaj +4 more sources
Recent Advances in the Development of Tetrazine Ligation Tools for Pretargeted Nuclear Imaging
Pharmaceuticals, 2022 Tetrazine ligation has gained interest as a bio-orthogonal chemistry tool within the last decade. In nuclear medicine, tetrazine ligation is currently being explored for pretargeted approaches, which have the potential to revolutionize state-of-the-art ...
Rocío García-Vázquez +2 more
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Enhanced control of bioactivity of tissue plasminogen activator (tPA) through domain-directed enzymatic oxidation of terminal galactose [PDF]
BioImpacts, 2022 Introduction: In targeted enzyme prodrug constructs, it is critical to control the bioactivity of the drug in its prodrug form. The preparation of such constructs often involves conjugation reactions directed to functional groups on amino acid side ...
Wael A. Mahdi +4 more
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Pretargeted Radioimmunotherapy
International Journal of Radiation Oncology*Biology*Physics, 2006 This brief review covers the concept of pretargeted radioimmunotherapy and summarize the results obtained in preclinical animal models and initial phase I clinical trials. Reagents studied have been a bifunctional antibody prepared by crosslinking Fab' fragments from two antibodies with different specificity, one binding the target antigen expressed on
Ruby F, Meredith, Donald J, Buchsbaum
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Dual Radionuclide Theranostic Pretargeting [PDF]
Molecular Pharmaceutics, 2019 Recent years have played witness to the advent of nuclear theranostics: the synergistic use of "matched pair" radiopharmaceuticals for diagnostic imaging and targeted radiotherapy. In this investigation, we report the extension of this concept to in vivo pretargeting based on the rapid and bioorthogonal inverse electron demand Diels-Alder reaction ...
Outi Keinänen +7 more
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Pretargeted Imaging and Therapy [PDF]
Journal of Nuclear Medicine, 2017 In vivo pretargeting stands as a promising approach to harnessing the exquisite tumor-targeting properties of antibodies for nuclear imaging and therapy while simultaneously skirting their pharmacokinetic limitations. The core premise of pretargeting lies in administering the targeting vector and radioisotope separately and having the 2 components ...
Mohamed, Altai +4 more
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A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives. [PDF]
PLoS ONE, 2016 A convenient strategy to radiolabel a hydrazinonicotonic acid (HYNIC)-derived tetrazine with 99mTc was developed, and its utility for creating probes to image bone metabolism and bacterial infection using both active and pretargeting strategies was ...
Alyssa Vito +13 more
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Biomedical and Biotechnology Research Journal, 2022 Background: Radiobioconjugate targeting using monoclonal antibodies linked to a high-energy radionuclide is a promising approach for treating metastatic cancer. The central problem of radiobioconjugate targeting is the small fraction of radiobioconjugate
Pankaj Garg
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Pretargeted imaging beyond the blood–brain barrier [PDF]
RSC Medicinal Chemistry, 2023 By screening a library of 18 F-labeled tetrazines, we identified tetrazines which showed high pretargeted PET imaging contrast beyond the blood–brain-barrier.
Vladimir Shalgunov +16 more
openaire +5 more sources