IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications [PDF]
Molecules, 2021 The pretargeting strategy has recently emerged in order to overcome the limitations of direct targeting, mainly in the field of radioimmunotherapy (RIT).
Maryana Handula +2 more
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Perfluoroaryl Azide Staudinger Reaction: A Fast and Bioorthogonal Reaction [PDF]
Angewandte Chemie - International Edition, 2017 Abstract We report a fast Staudinger reaction between perfluoroaryl azides (PFAAs) and aryl phosphines, which occurs readily under ambient conditions. A rate constant as high as 18 m −1 s −1 was obtained between ...
Olof Ramström +2 more
exaly +5 more sources
A catalyst-free bioorthogonal reaction for malononitrile addition to azodicarboxylates [PDF]
Nature CommunicationsDeveloping bioorthogonal reactions that enable fundamental exploration of biological processes remains a key pursuit of chemical biology. We report here malononitrile addition to azodicarboxylate as a distinct class of catalyst-free bioorthogonal ...
Honggui Huang +10 more
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Bioorthogonal Reaction of o‐Quinone with Furan‐2(3H)‐One for Site‐Selective Tyrosine Conjugation and Construction of Bispecific Antibody Complexes [PDF]
Advanced ScienceBioorthogonal reactions enable the chemical conjugation of functional moieties to native proteins and empower the development of new diagnostic tools and therapeutics.
Hongfei Chen +13 more
doaj +2 more sources
Molecules, 2016 The emergence of bioorthogonal reactions has greatly broadened the scope of biomolecule labeling and detecting. Of all the bioorthogonal reactions that have been developed, the copper-catalyzed azide-alkyne cycloaddition (CuAAC) is the most widely ...
Li Li, Zhiyuan Zhang
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Photoactivatable Fluorogenic Labeling via Turn‐On “Click‐Like” Nitroso‐Diene Bioorthogonal Reaction [PDF]
Advanced Science, 2019 Fluorogenic labeling enables imaging cellular molecules of interest with minimal background. This process is accompanied with the notable increase of the quantum yield of fluorophore, thus minimizing the background signals from unactivated ...
Bai Li +9 more
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The evolution of click chemistry: from classical reactions to next-generation platforms [PDF]
RSC AdvancesClick chemistry has transformed modern synthetic chemistry by providing efficient, selective, and modular strategies for constructing complex molecular structures.
Seyed Mohammad Mahdi Dadfar +1 more
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Critical re-evaluation of experimental settings with fluorescent probes for bioorthogonal chemistry with palladium antimony inactivation-resistant catalyst [PDF]
Scientific ReportsBioorthogonal reactions, both in vitro and in vivo, show great promise in fluorescent proteins labelling and for the development of bioorthogonal anticancer therapies. In this work, we focus on palladium-catalysed deprotection chemistry.
Jana Kurcova +7 more
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A Genetically Encoded Isonitrile Lysine for Orthogonal Bioorthogonal Labeling Schemes
Molecules, 2021 Bioorthogonal click-reactions represent ideal means for labeling biomolecules selectively and specifically with suitable small synthetic dyes. Genetic code expansion (GCE) technology enables efficient site-selective installation of bioorthogonal handles ...
Ágnes Szatmári +8 more
doaj +1 more source
Isocyanides: Promising Functionalities in Bioorthogonal Labeling of Biomolecules
Frontiers in Chemistry, 2021 Isocyanides have drawn increasing attention in biological applications due to their attractive properties and unique reactivities, which can undergo various reactions, such as multicomponent reactions, α-addition reactions, [4 + 1] cycloaddition ...
Yuchen Zhu +6 more
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