Results 1 to 10 of about 10,614 (137)

Nanozymes with bioorthogonal reaction for intelligence nanorobots [PDF]

Biophysics Reports, 2021
Bioorthogonal reactions have attained great interest and achievements in various fields since its first appearance in 2003. Compared to traditional chemical reactions, bioorthogonal chemical reactions mediated by transition metals catalysts can occur under physiological conditions in the living system without interfering with or damaging other ...
Sun, Si, Chen, Xinzhu, Chen, Jing, Wang, Junying, Zhang, Xiao-dong   +4 more
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IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications [PDF]

Molecules, 2021
The pretargeting strategy has recently emerged in order to overcome the limitations of direct targeting, mainly in the field of radioimmunotherapy (RIT). This strategy is directly dependent on chemical reactions, namely bioorthogonal reactions, which have been developed for their ability to occur under physiological conditions. The Staudinger ligation,
Maryana Handula, Kuo-Ting Chen, Yann Seimbille   +2 more
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Perfluoroaryl Azide Staudinger Reaction: A Fast and Bioorthogonal Reaction [PDF]

Angewandte Chemie International Edition, 2017
AbstractWe report a fast Staudinger reaction between perfluoroaryl azides (PFAAs) and aryl phosphines, which occurs readily under ambient conditions. A rate constant as high as 18 m−1 s−1 was obtained between methyl 4‐azido‐2,3,5,6‐tetrafluorobenzoate and methyl 2‐(diphenylphosphanyl)benzoate in CD3CN/D2O.
Madanodaya Sundhoro, Seaho Jeon, Jaehyeung Park, Olof Ramström, Mingdi Yan   +4 more
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Co-opting a Bioorthogonal Reaction for Oncometabolite Detection [PDF]

Journal of the American Chemical Society, 2016
Dysregulated metabolism is a hallmark of many diseases, including cancer. Methods to fluorescently detect metabolites have the potential to enable new approaches to cancer detection and imaging. However, fluorescent sensing methods for naturally occurring cellular metabolites are relatively unexplored.
Thomas T, Zengeya, Julie M, Garlick, Rhushikesh A, Kulkarni, Mikayla, Miley, Allison M, Roberts, Youfeng, Yang, Daniel R, Crooks, Carole, Sourbier, W Marston, Linehan, Jordan L, Meier   +9 more
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Bioorthogonal Reactions in Animals

ChemBioChem, 2020
AbstractThe advent of bioorthogonal chemistry has led to the development of powerful chemical tools that enable increasingly ambitious applications. In particular, these tools have made it possible to achieve what is considered to be the holy grail of many researchers involved in chemical biology: to perform unnatural chemical reactions within living ...
Karine Porte, Maxime Riberaud, Rémi Châtre, Davide Audisio, Sébastien Papot, Frédéric Taran   +5 more
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Nanostructured Heterogeneous Catalysts for Bioorthogonal Reactions

Angewandte Chemie, 2023
AbstractBioorthogonal chemistry has inspired a new subarea of chemistry providing a powerful tool to perform novel biocompatible chemospecific reactions in living systems. Following the premise that they do not interfere with biological functions, bioorthogonal reactions are increasingly applied in biomedical research, particularly with respect to ...
Ana Sousa‐Castillo, Andrea Mariño‐López, Begoña Puértolas, Miguel A. Correa‐Duarte   +3 more
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Designing Bioorthogonal Reactions for Biomedical Applications

Research, 2023
Bioorthogonal reactions are a class of chemical reactions that can be carried out in living organisms without interfering with other reactions, possessing high yield, high selectivity, and high efficiency. Since the first proposal of the conception by Professor Carolyn Bertozzi in 2003, bioorthogonal chemistry has attracted great attention and has been
Qingfei Zhang, Gaizhen Kuang, Li Wang, Ping Duan, Weijian Sun, Fangfu Ye   +5 more
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Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation [PDF]

, 2020
An inverse electron demand Diels–Alder reaction between tetrazine and trans-cyclooctene (TCO) holds great promise for protein modification and manipulation.
Chudasama, V., Kuan, S., Nogueira, J., Raabe, M., Weil, T., Xu, L., Zegota, M.   +6 more
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Constructing New Bioorthogonal Reagents and Reactions [PDF]

Accounts of Chemical Research, 2018
Chemical tools are transforming our understanding of biomolecules and living systems. Included in this group are bioorthogonal reagents-functional groups that are inert to most biological species, but can be selectively ligated with complementary probes, even in live cells and whole organisms.
R. David Row, Jennifer A. Prescher
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Bioorthogonal Reactions in Activity-Based Protein Profiling [PDF]

Molecules, 2020
Activity-based protein profiling (ABPP) is a powerful technique to label and detect active enzyme species within cell lysates, cells, or whole animals. In the last two decades, a wide variety of applications and experimental read-out techniques have been pursued in order to increase our understanding of physiological and pathological processes, to ...
Verhelst, Steven H.L., Bonger, Kimberly M., Willems, Lianne I.   +2 more
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