Bioorthogonal Reactions of Triarylphosphines and Related Analogues
Chemical Reviews, 2021 Bioorthogonal phosphines were introduced in the context of the Staudinger ligation over 20 years ago. Since that time, phosphine probes have been used in myriad applications to tag azide-functionalized biomolecules. The Staudinger ligation also paved the way for the development of other phosphorus-based chemistries, many of which are widely employed in
Tyler K. Heiss +2 more
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Development and Applications of the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) as a Bioorthogonal Reaction. [PDF]
Molecules, 2016 Li L, Zhang Z.
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Improving bioorthogonal protein ubiquitylation by click reaction [PDF]
Bioorganic & Medicinal Chemistry, 2013 Posttranslational modification of proteins with ubiquitin (ubiquitylation) regulates numerous cellular processes. Besides functioning as a signal for proteasomal degradation, ubiquitylation has also non-proteolytic functions by altering the biochemical properties of the modified protein.
Schneider, Daniel +4 more
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Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening. [PDF]
, 2015 Density functional theory (DFT) calculations and experiments in tandem led to discoveries of new reactivities and selectivities involving bioorthogonal sydnone cycloadditions.
Houk, KN +3 more
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Human T cell glycosylation and implications on immune therapy for cancer [PDF]
, 2020 Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico +3 more
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Modulating the catalytic activity of enzyme-like nanoparticles through their surface functionalization [PDF]
, 2017 The inclusion of transition metal catalysts into nanoparticle scaffolds permits the creation of catalytic nanosystems (nanozymes) able to imitate the behaviour of natural enzymes.
Cao-Milán, R. +9 more
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Recent Advances in Bioorthogonal Reactions
CHIMIA, 2019 The ability to selectively perform chemical reactions within living systems has transformed the field of Chemical Biology. These chemoselective processes have had a major scientific impact by enabling studies of cellular processes, producing tools for the ligations of large biomolecules, and advancing our ability to image or track small ...
Schäfer, Rebecca J.B. +2 more
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Noncanonical Amino Acids in the Interrogation of Cellular Protein Synthesis [PDF]
, 2011 Proteins in living cells can be made receptive to bioorthogonal chemistries through metabolic labeling with appropriately designed noncanonical amino acids (ncAAs).
Ngo, John T., Tirrell, David A.
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Systematic screening of different polyglycerin‐based dienophile macromonomers for efficient nanogel formation through IEDDA inverse nanoprecipitation [PDF]
, 2019 Alternatives for strain‐promoted azide–alkyne cycloaddition (SPAAC) chemistries are needed because of the employment of expensive and not easily scalable precursors such as bicyclo[6.1.0]non‐4‐yne (BCN).
Haag, Rainer +2 more
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Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]
, 2019 The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B +3 more
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