Results 31 to 40 of about 5,912 (181)

Silylated biomolecules: Versatile components for bioinks

Frontiers in Bioengineering and Biotechnology, 2022
Physical hydrogels prepared from natural biopolymers are the most popular components for bioinks. However, to improve the mechanical properties of the network, in particular its durability for long-lasting tissue engineering applications or its stiffness
Titouan Montheil, Titouan Montheil, Matthieu Simon, Matthieu Simon, Danièle Noël, Ahmad Mehdi, Gilles Subra, Cécile Echalier   +7 more
doaj   +1 more source

Application of the Inverse-Electron-Demand Diels-Alder Reaction for Metabolic Glycoengineering

Frontiers in Chemistry, 2021
The inverse electron-demand Diels-Alder (IEDDA or DAinv) reaction is an emerging bioorthogonal ligation reaction that finds application in all areas of chemistry and chemical biology.
Lisa Maria Haiber, Markus Kufleitner, Valentin Wittmann   +2 more
doaj   +1 more source

A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Frontiers in Chemistry, 2021
Bioorthogonal chemistry allows rapid and highly selective reactivity in biological environments. The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a classic bioorthogonal reaction routinely used to modify azides or alkynes that have been ...
Birthe Meineke, Birthe Meineke, Johannes Heimgärtner, Johannes Heimgärtner, Alexander J. Craig, Michael Landreh, Lindon W. K. Moodie, Lindon W. K. Moodie, Simon J. Elsässer, Simon J. Elsässer   +9 more
doaj   +1 more source

Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells

Nature Communications, 2018
Transition-metal catalysis in living cells poses numerous challenges in terms of biocompatibility, and complex stability and reactivity. Here, the authors report a bioorthogonal gold-catalyzed C-C coupling reaction, occurring in living mammalian cells ...
Cristian Vidal, María Tomás-Gamasa, Paolo Destito, Fernando López, José L. Mascareñas   +4 more
doaj   +1 more source

Bioorthogonal Reactions in Bioimaging

Topics in Current Chemistry
AbstractVisualization of biomolecules in their native environment or imaging-aided understanding of more complex biomolecular processes are one of the focus areas of chemical biology research, which requires selective, often site-specific labeling of targets. This challenging task is effectively addressed by bioorthogonal chemistry tools in combination
Eszter Kozma, Péter Kele
openaire   +2 more sources

A Short Review of Research Progress on the Synthesis Approaches of Aza-Dibenzocyclooctyne Derivatives

Molecules, 2023
Cyclooctyne molecules have found wide applications in the strain-promoted azide–alkyne cycloaddition (SPAAC) reactions, which avoid the biotoxicity caused by the use of Cu(I) catalysts.
Yinming He, Li Liu, Liang Cheng
doaj   +1 more source

Switching azide and alkyne tags on bioorthogonal reporters in metabolic labeling of sialylatedglycoconjugates: a comparative study

Scientific Reports, 2022
Sialylation of cell surface glycans plays an essential role in cell–cell interaction and communication of cells with their microenvironment. Among the tools that have been developed for the study of sialylation in living cells, metabolic oligosaccharide ...
Jodie Scache, Vincent Rigolot, Cédric Lion, Marlène Mortuaire, Tony Lefebvre, Christophe Biot, Anne-Sophie Vercoutter-Edouart   +6 more
doaj   +1 more source

Prodrug activation by 4,4’-bipyridine-mediated aromatic nitro reduction

Nature Communications
Unleashing prodrugs through nitro-reduction is a promising strategy in cancer treatment. In this study, we present a unique bioorthogonal reaction for aromatic nitro reduction, mediated by 4,4‘-bipyridine. The reaction is a rare example of organocatalyst-
Qing Wang, Yikang Song, Shuowei Yuan, Yaoji Zhu, Wenjing Wang, Ling Chu   +5 more
doaj   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Luciferase-induced photoreductive uncaging of small-molecule effectors

Nature Communications, 2018
Bioluminescence resonance energy transfer (BRET) has been mostly employed in imaging applications. Here the authors use BRET to activate a ruthenium-based photocatalyst and perform a bioorthogonal chemical reaction, which can be used to uncage small ...
Eric Lindberg, Simona Angerani, Marcello Anzola, Nicolas Winssinger   +3 more
doaj   +1 more source