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Signal Transduction and Targeted Therapy, 2022 Bioorthogonal chemistry reactions occur in physiological conditions without interfering with normal physiological processes. Through metabolic engineering, bioorthogonal groups can be tagged onto cell membranes, which selectively attach to cargos with ...
Yaping Li, Wenzhe Yi
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Designing Bioorthogonal Reactions for Biomedical Applications
Research, 2023 Bioorthogonal reactions are a class of chemical reactions that can be carried out in living organisms without interfering with other reactions, possessing high yield, high selectivity, and high efficiency.
Qingfei Zhang +5 more
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Bioorthogonal Ligations and Cleavages in Chemical Biology
ChemistryOpen, 2020 Bioorthogonal reactions including the bioorthogonal ligations and cleavages have become an active field of research in chemical biology, and they play important roles in chemical modification and functional regulation of biomolecules.
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Ultrasound‐Recharged Sub‐Nanometer Palladium Catalysts for on‐Demand and Self‐Terminating Bioorthogonal Prodrug Activation in Cancer Therapy [PDF]
Advanced ScienceBioorthogonal catalysis holds great promise for precision cancer therapy, yet its clinical translation is critically hindered by the lack of reliable control over catalytic activity.
Daqing Xia +9 more
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Red light-responsive bioorthogonal chemistry enabled on-demand prodrug activation for cancer therapy [PDF]
Acta Pharmaceutica Sinica BLight-driven chemistry has revolutionized modern medicine, enabling precise disease detection and on-demand therapeutic interventions with high spatiotemporal accuracy. However, despite tremendous advances in bioorthogonal reactions, photoclick chemistry-
Hanzeng Cheng +15 more
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Programmable nanomedicine via bioorthogonal molecular engineering [PDF]
Nano ConvergenceBioorthogonal chemistry provides a versatile strategy for programming nanomedicines beyond static carrier design. It enables post-synthetic installation of functional modules on nanoparticle surfaces, spatiotemporal control of payload activation and ...
Sunwoo Im, Seyoung Koo, Jong Seung Kim
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Tetrazine bioorthogonal chemistry derived in vivo imaging
Frontiers in Molecular Biosciences, 2022 Bioorthogonal chemistry represents plenty of highly efficient and biocompatible reactions that proceed selectively and rapidly in biological situations without unexpected side reactions towards miscellaneous endogenous functional groups.
Gaoxiang Zhao +9 more
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Molecules, 2021 The traceless Staudinger ligation with its two variants is a powerful biorthogonal conjugation method not only for the connection of biomolecules, but also for the introduction of fluorescence- or radiolabels under mild reaction conditions.
Constantin Mamat +3 more
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Clearing and Masking Agents in Pretargeting Strategies
Pharmaceuticals, 2023 ‘Pretargeting’ led to increased target-to-background ratios of nanomedicines in short timeframes. However, clearing or masking agents are needed to reach the full potential of pretargeted approaches.
Markus Staudt, Matthias M. Herth
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Covalent attachments of 5(6) acylchloride fluorescein and 5(6) thiophenol fluorescein compounds with hen egg white lysozyme and serum bovine albumin as bioorthogonal reactions [PDF]
شیمی کاربردی روز, 2019 Bioorthogonal reactions are known as types of chemical reactions without the interference from biological reactions within the living systems. The requirements for such reactions include activities in aqueous environment, mild temperature, and ...
Hamid Reza Kalhor, Mohsen Rezaei
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