Development of Bioorthogonal Reactions and Their Applications in Bioconjugation [PDF]
Molecules, 2015 Biomolecule labeling using chemical probes with specific biological activities has played important roles for the elucidation of complicated biological processes.
Mengmeng Zheng +4 more
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Designing Bioorthogonal Reactions for Biomedical Applications [PDF]
Research, 2023 Bioorthogonal reactions are a class of chemical reactions that can be carried out in living organisms without interfering with other reactions, possessing high yield, high selectivity, and high efficiency.
Qingfei Zhang +5 more
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Bioorthogonal Reactions in Activity-Based Protein Profiling [PDF]
Molecules, 2020 Activity-based protein profiling (ABPP) is a powerful technique to label and detect active enzyme species within cell lysates, cells, or whole animals. In the last two decades, a wide variety of applications and experimental read-out techniques have been
Steven H. L. Verhelst +2 more
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IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications [PDF]
Molecules, 2021 The pretargeting strategy has recently emerged in order to overcome the limitations of direct targeting, mainly in the field of radioimmunotherapy (RIT).
Maryana Handula +2 more
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Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing [PDF]
Acta Pharmaceutica Sinica B, 2023 Cell membrane camouflaged nanoparticles have been widely used in the field of drug leads discovery attribute to their unique biointerface targeting function.
Xiaolin Zhang +5 more
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Molecules, 2016 The emergence of bioorthogonal reactions has greatly broadened the scope of biomolecule labeling and detecting. Of all the bioorthogonal reactions that have been developed, the copper-catalyzed azide-alkyne cycloaddition (CuAAC) is the most widely ...
Li Li, Zhiyuan Zhang
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Chemical Reporters and Their Bioorthogonal Reactions for Labeling Protein O-GlcNAcylation [PDF]
Molecules, 2018 Protein O-GlcNAcylation is a non-canonical glycosylation of nuclear, mitochondrial, and cytoplasmic proteins with the attachment of a single O-linked β-N-acetyl-glucosamine (O-GlcNAc) moiety.
Eun Ju Kim
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Tetrazine-based bioorthogonal reactions to image hypoxia in cancer cells [PDF]
iScienceSummary: Suboptimal oxygen supply in solid tumors controls a variety of cancer hallmarks and impairs responsiveness to anticancer treatments. Yet, tools to visualize hypoxia in cancer are still limited.
Sara Boumya +9 more
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The evolution of click chemistry: from classical reactions to next-generation platforms [PDF]
RSC AdvancesClick chemistry has transformed modern synthetic chemistry by providing efficient, selective, and modular strategies for constructing complex molecular structures.
Seyed Mohammad Mahdi Dadfar +1 more
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Red light-responsive bioorthogonal chemistry enabled on-demand prodrug activation for cancer therapy [PDF]
Acta Pharmaceutica Sinica BLight-driven chemistry has revolutionized modern medicine, enabling precise disease detection and on-demand therapeutic interventions with high spatiotemporal accuracy. However, despite tremendous advances in bioorthogonal reactions, photoclick chemistry-
Hanzeng Cheng +15 more
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