Results 41 to 50 of about 1,215,519 (212)

Biomimetic and bioorthogonal nanozymes for biomedical applications

Nano Convergence, 2023
Nanozymes mimic the function of enzymes, which drive essential intracellular chemical reactions that govern biological processes. They efficiently generate or degrade specific biomolecules that can initiate or inhibit biological processes, regulating ...
Changjoon Keum, Cristina-Maria Hirschbiegel, Soham Chakraborty, Soyeong Jin, Youngdo Jeong, Vincent M. Rotello   +5 more
doaj   +1 more source

Diazo group as a new chemical reporter for bioorthogonal labelling of biomolecules† [PDF]

RSC Advances, 2014
Diazoacetyl groups have been shown to undergo spontaneous cycloaddition reactions with strained alkenes and alkynes. The rates of reaction are similar to the equivalent reactions of azide groups.
Laia Josa-Culleré, Yelena A. Wainman, Kevin M. Brindle, Finian J. Leeper   +3 more
doaj   +1 more source

Click Chemistry in Human Cancer Research

Zhongliu Fangzhi Yanjiu
As one of the typical bioorthogonal chemistry reactions, click chemistry joins molecules similar to “Lego”. Bioorthogonal click chemistry is used to modify cancer cells, design antitumor drugs, delivery drugs, manipulate immune cells, and help ...
Baihong ZHANG, Hongyun YUE
doaj   +2 more sources

Co-opting a Bioorthogonal Reaction for Oncometabolite Detection [PDF]

Journal of the American Chemical Society, 2016
Dysregulated metabolism is a hallmark of many diseases, including cancer. Methods to fluorescently detect metabolites have the potential to enable new approaches to cancer detection and imaging. However, fluorescent sensing methods for naturally occurring cellular metabolites are relatively unexplored.
Thomas T, Zengeya, Julie M, Garlick, Rhushikesh A, Kulkarni, Mikayla, Miley, Allison M, Roberts, Youfeng, Yang, Daniel R, Crooks, Carole, Sourbier, W Marston, Linehan, Jordan L, Meier   +9 more
openaire   +2 more sources

Boronic Acids as Bioorthogonal Probes for Site‐Selective Labeling of Proteins [PDF]

, 2018
Over the past two decades, bioorthogonal chemistry has become a preferred tool to achieve site‐selective modifications of proteins. However, there are only a handful of commonly applied bioorthogonal reactions and they display some limitations, such as ...
Akgun, Burcin, Hall, Dennis G.
core   +1 more source

Self-Assembly of Proteolysis Targeting Chimeras Via Reversible Bioorthogonal Reactions [PDF]

, 2022
Targeted protein degradation (TPD) by PROteolysis TArgeting Chimeras (PROTACs) is of great interest for probe molecule and drug development. However, current bivalent PROTACs are rule-breaking molecules with sub-optimal cellular permeability, solubility,
Madeline, Balzarini, Sarah, Giardina, Francis, Barany, Weijun, Gui, Thomas, Kodadek   +4 more
core   +2 more sources

Development and application of bond cleavage reactions in bioorthogonal chemistry

, 2016
Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as an unprecedented technique to dissect native biological processes through chemistry-enabled strategies. However, current concepts of bioorthogonal chemistry have
Li, Jie, Chen, Peng R.
core   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Rapid Photogelation of Low‐Concentration Polymer Solutions via Photodimerization of o‐Ethylnitrobenzene

Advanced Science, EarlyView.
Upon UV irradiation, flexible and tough hydrogels are formed rapidly (>0.5 s) from dilute (>0.5 wt%) solutions of o‐ethylnitrobenzene–modified PVA. At ∼1.5 wt%, the hydrogels withstand up to 10 MPa compression, remain handleable even after 200‐fold swelling.
Masaaki Okihara, Ayaka Tomoda, Kana Morishita, Toshiyuki Takagi, Kimio Sumaru   +4 more
wiley   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source