Pharmaceutics, 2023 The availability of several bioorthogonal reactions that can proceed selectively and efficiently under physiologically relevant conditions has garnered the interest of biochemists and organic chemists alike. Bioorthogonal cleavage reactions represent the
Nisarg Soni +9 more
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Overview of Syntheses and Molecular-Design Strategies for Tetrazine-Based Fluorogenic Probes
Molecules, 2021 Various bioorthogonal chemistries have been used for fluorescent imaging owing to the advantageous reactions they employ. Recent advances in bioorthogonal chemistry have revolutionized labeling strategies for fluorescence imaging, with inverse electron ...
Sang-Kee Choi, Jonghoon Kim, Eunha Kim
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Covalent attachments of 5(6) acylchloride fluorescein and 5(6) thiophenol fluorescein compounds with hen egg white lysozyme and serum bovine albumin as bioorthogonal reactions [PDF]
شیمی کاربردی روز, 2019 Bioorthogonal reactions are known as types of chemical reactions without the interference from biological reactions within the living systems. The requirements for such reactions include activities in aqueous environment, mild temperature, and ...
Hamid Reza Kalhor, Mohsen Rezaei
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Isocyanides: Promising Functionalities in Bioorthogonal Labeling of Biomolecules
Frontiers in Chemistry, 2021 Isocyanides have drawn increasing attention in biological applications due to their attractive properties and unique reactivities, which can undergo various reactions, such as multicomponent reactions, α-addition reactions, [4 + 1] cycloaddition ...
Yuchen Zhu +6 more
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Staudinger Ligation and Reactions – From Bioorthogonal Labeling to Next‐Generation Biopharmaceuticals [PDF]
, 2022 In this review, we highlight groundbreaking discoveries and applications of Staudinger reactions in the molecular life sciences, starting from the engineering of the Staudinger ligation as a bioorthogonal reaction until most recent applications in modern
Hackenberger, Christian +1 more
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Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
Molecules, 2020 Prodrugs, which remain inert until they are activated under appropriate conditions at the target site, have emerged as an attractive alternative to drugs that lack selectivity and show off-target effects.
Yayue Wang +3 more
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Should I Stay or Should I Go-Leveraging an Overlooked Feature of Click-to-Release Chemistry for Affinity Labeling. [PDF]
Angew Chem Int Ed EnglClick‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Kern D +9 more
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Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging. [PDF]
, 2021 Owing to their bioorthogonality, transition metals have become very popular in the development of biocompatible bond-cleavage reactions. However, many approaches require design and synthesis of complex ligands or formulation of nanoparticles which often ...
Latocheski, Eloah +15 more
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Improving bioorthogonal protein ubiquitylation by click reaction [PDF]
Bioorganic & Medicinal Chemistry, 2013 Posttranslational modification of proteins with ubiquitin (ubiquitylation) regulates numerous cellular processes. Besides functioning as a signal for proteasomal degradation, ubiquitylation has also non-proteolytic functions by altering the biochemical properties of the modified protein.
Schneider, Daniel +4 more
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Azide-based bioorthogonal chemistry: Reactions and its advances in cellular and biomolecular imaging
, 2021 Since the term “bioorthogonal” was first demonstrated in 2003, new tools for bioorthogonal chemistry have been rapidly developed. Bioorthogonal chemistry has now been widely utilized for applications in imaging various biomolecules, such as proteins ...
Samira Husen Alamudi +7 more
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