Results 11 to 20 of about 1,215,519 (212)

Bioorthogonal Reactions of Triarylphosphines and Related Analogues. [PDF]

Chem Rev, 2021
Bioorthogonal phosphines were introduced in the context of the Staudinger ligation over 20 years ago. Since that time, phosphine probes have been used in myriad applications to tag azide-functionalized biomolecules. The Staudinger ligation also paved the way for the development of other phosphorus-based chemistries, many of which are widely employed in
Heiss TK, Dorn RS, Prescher JA.
europepmc   +8 more sources

Bioorthogonal Decaging Reactions for Targeted Drug Activation [PDF]

CHIMIA, 2018
Bioorthogonal decaging reactions are highly selective transformations which involve the cleavage of a protecting group from a molecule of interest.
Sarah Davies, Benjamin J. Stenton, Gonçalo J. L. Bernardes   +2 more
doaj   +8 more sources

Bioorthogonal Reactions in Animals

ChemBioChem, 2020
AbstractThe advent of bioorthogonal chemistry has led to the development of powerful chemical tools that enable increasingly ambitious applications. In particular, these tools have made it possible to achieve what is considered to be the holy grail of many researchers involved in chemical biology: to perform unnatural chemical reactions within living ...
Karine Porte, Maxime Riberaud, Rémi Châtre, Davide Audisio, Sébastien Papot, Frédéric Taran   +5 more
core   +5 more sources

Recent Advances in Bioorthogonal Reactions

CHIMIA, 2019
The ability to selectively perform chemical reactions within living systems has transformed the field of Chemical Biology. These chemoselective processes have had a major scientific impact by enabling studies of cellular processes, producing ...
Rebecca J. B. Schäfer, Matthew R. Aronoff, Helma Wennemers   +2 more
doaj   +5 more sources

Click-Triggered Bioorthogonal Bond-Cleavage Reactions [PDF]

Topics in Current Chemistry
Abstract Bioorthogonal bond-cleavage reactions have evolved into powerful tools for chemical biology, representing a promising strategy for achieving controlled release of molecules under physiologically relevant conditions, even in living organisms.
Patrick Keppel, Sebastian Hecko, Hannes Mikula   +2 more
openaire   +3 more sources

Constructing New Bioorthogonal Reagents and Reactions [PDF]

Accounts of Chemical Research, 2018
Chemical tools are transforming our understanding of biomolecules and living systems. Included in this group are bioorthogonal reagents-functional groups that are inert to most biological species, but can be selectively ligated with complementary probes, even in live cells and whole organisms.
R. David Row, Jennifer A. Prescher
openaire   +6 more sources

Ultrasound‐Recharged Sub‐Nanometer Palladium Catalysts for on‐Demand and Self‐Terminating Bioorthogonal Prodrug Activation in Cancer Therapy [PDF]

Advanced Science
Bioorthogonal catalysis holds great promise for precision cancer therapy, yet its clinical translation is critically hindered by the lack of reliable control over catalytic activity.
Daqing Xia, Lei Liu, Shuang Jin, Guangxu Fang, Chang Yu, Yunyun Wu, Lunli Xiang, Hongrui Zhu, Zhenqiang Wang, Jixi Zhang   +9 more
doaj   +2 more sources

Bioorthogonal Reactions in Bioimaging. [PDF]

Top Curr Chem (Cham)
AbstractVisualization of biomolecules in their native environment or imaging-aided understanding of more complex biomolecular processes are one of the focus areas of chemical biology research, which requires selective, often site-specific labeling of targets. This challenging task is effectively addressed by bioorthogonal chemistry tools in combination
Kozma E, Kele P.
europepmc   +3 more sources

Critical re-evaluation of experimental settings with fluorescent probes for bioorthogonal chemistry with palladium antimony inactivation-resistant catalyst [PDF]

Scientific Reports
Bioorthogonal reactions, both in vitro and in vivo, show great promise in fluorescent proteins labelling and for the development of bioorthogonal anticancer therapies. In this work, we focus on palladium-catalysed deprotection chemistry.
Jana Kurcova, Marie Kudlickova Peskova, Lukas Jeremias, Sofiia Orlova, Jan Bilek, Paulina Takacsova, Zbynek Heger, Vladimir Pekarik   +7 more
doaj   +2 more sources

Fluorogenic Coumarins Activated via Bioorthogonal Reactions. [PDF]

J Org Chem
Fluorogenic bioorthogonal reagents enable facile detection in complex environments. While useful for real-time imaging, few such probes are available. Existing tools also exploit similar mechanisms for signal turn-on, precluding multiplexed applications. To address these gaps, we developed a palette of cyclopropenone (CpO) scaffolds that are activated
Lin-Jones HM, Chen S, Seo Y, Pham KQ, Prescher JA.   +4 more
europepmc   +3 more sources