Results 31 to 40 of about 17,092 (277)
Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation. [PDF]
, 2021 A self-immolative bioorthogonal conditionally cleavable linker based on Grob fragmentation is described. It is derived from 1,3-aminocyclohexanols and allows the release of sulfonate-containing compounds in aqueous media.
Corzana, Francisco [0000-0001-5597-8127] +48 more
core +3 more sources
Metabolic Engineering Optimizes Bioorthogonal Glycan Labeling in Living Cells [PDF]
, 2021 Metabolic oligosaccharide engineering (MOE) has fundamentally contributed to our understanding of protein glycosylation. Efficient MOE reagents are activated into nucleotide-sugars by cellular biosynthetic machineries, introduced into glycoproteins and ...
Junwon, Choi +13 more
core +1 more source
Journal of Lipid Research, 2020 Gram-negative bacteria possess an asymmetric outer membrane (OM) composed primarily of lipopolysaccharides (LPSs) on the outer leaflet and phospholipids (PLs) on the inner leaflet.
Inga Nilsson +5 more
doaj +1 more source
Bioorthogonal Chemistry in Cellular Organelles
Topics in Current Chemistry, 2023 AbstractWhile bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this review, we highlight diverse examples of bioorthogonal reactions used to investigate the roles of biomolecules and biological processes as well as advanced imaging techniques within cellular
Veronika Šlachtová +3 more
openaire +3 more sources
Should I Stay or Should I Go-Leveraging an Overlooked Feature of Click-to-Release Chemistry for Affinity Labeling. [PDF]
Angew Chem Int Ed EnglClick‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Kern D +9 more
europepmc +3 more sources
Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs
Molecules, 2020 Prodrugs, which remain inert until they are activated under appropriate conditions at the target site, have emerged as an attractive alternative to drugs that lack selectivity and show off-target effects.
Yayue Wang +3 more
doaj +1 more source
Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation
Molecules, 2021 Novel bioorthogonal tools enable the development of new biomedical applications. Here we report the concise synthesis of a series of aryl-functionalized cyclobutene analogues using commercially available starting materials.
Jiayu Sun +4 more
doaj +1 more source
Bioorthogonal CRISPR/Cas9‐Drug Conjugate: A Combinatorial Nanomedicine Platform
Advanced Science, 2023 Bioconjugation of proteins can substantially expand the opportunities in biopharmaceutical development, however, applications are limited for the gene editing machinery despite its tremendous therapeutic potential.
Marcel Janis Beha +9 more
doaj +1 more source
Cell-surface Labeling via Bioorthogonal HostGuest Chemistry
, 2021 The widespread adoption of the bioorthogonal chemical reporter strategy revolutionized chemical biology. However, its translation to living mammals has been challenging, due to the size/stability properties of the chemical reporter group and/or the ...
Selena Hernandez +5 more
core +1 more source
Biomolecules, 2020 Herein, we present the synthesis and application of a fluorogenic, large Stokes-shift (>100 nm), bioorthogonally conjugatable, membrane-permeable tetrazine probe, which can be excited at common laser line 488 nm and detected at around 600 nm.
Evelin Németh +3 more
doaj +1 more source