Results 51 to 60 of about 17,092 (277)

Kinugasa Reactions in Water: From Green Chemistry to Bioorthogonal Labelling

Molecules, 2015
The Kinugasa reaction has become an efficient method for the direct synthesis of β-lactams from substituted nitrones and copper(I) acetylides. In recent years, the reaction scope has been expanded to include the use of water as the solvent, and with ...
Mariya Chigrinova, Douglas A. MacKenzie, Allison R. Sherratt, Lawrence L. W. Cheung, John Paul Pezacki   +4 more
doaj   +1 more source

Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications

Pharmaceuticals, 2016
Human CK2 is a heterotetrameric constitutively active serine/threonine protein kinase and is an emerging target in current anti-cancer drug discovery. The kinase is composed of two catalytic CK2α subunits and two regulatory CK2β subunits.
Christian Nienberg, Anika Retterath, Kira-Sophie Becher, Thorsten Saenger, Henning D. Mootz, Joachim Jose   +5 more
doaj   +1 more source

Interfacial Bioorthogonal Cross-Linking [PDF]

ACS Macro Letters, 2014
Abstract Described herein is interfacial bioorthogonal cross-linking, the use of bioorthogonal chemistry to create and pattern biomaterials through diffusion-controlled gelation at the liquid-gel interface. The basis is a rapid (k2 284000 M–1 s–1) reaction between strained trans-cyclooctene (TCO) and tetrazine (Tz) derivatives ...
Zhang, Han, Dicker, Kevin T., Xu, Xian, Jia, Xinqiao, Fox, Joseph M.   +4 more
openaire   +2 more sources

Transition metal mediated bioorthogonal release

, 2022
Bioorthogonal chemistry offers powerful tools to study and manipulate biological systems without interfering with the biological processes. Of paramount interest is the possibility to exploit bioorthogonal tools to deliver novel therapeutic applications.

core   +2 more sources

A small azide-modified thiazole-based reporter molecule for fluorescence and mass spectrometric detection

Beilstein Journal of Organic Chemistry, 2014
Molecular probes are widely used tools in chemical biology that allow tracing of bioactive metabolites and selective labeling of proteins and other biomacromolecules.
Stefanie Wolfram, Hendryk Würfel, Stefanie H. Habenicht, Christine Lembke, Phillipp Richter, Eckhard Birckner, Rainer Beckert, Georg Pohnert   +7 more
doaj   +1 more source

Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging

Nature Communications
Bioorthogonal chemistry-mediated self-assembly holds great promise for dynamic molecular imaging in living organisms. However, existing approaches are limited to nanoaggregates with ‘always-on’ signals, suffering from high signal-to-background ratio (SBR)
Weiping Xu, Shujuan Yi, Jie Liu, Yu-Yan Jiang, Jia-Guo Huang   +4 more
semanticscholar   +1 more source

Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis

eLife, 2019
The functional mechanisms of membrane proteins are extensively investigated with cysteine mutagenesis. To complement cysteine-based approaches, we engineered a membrane protein with thiol-independent crosslinkable groups using azidohomoalanine (AHA), a ...
Kanchan Gupta, Gilman ES Toombes, Kenton J Swartz   +2 more
doaj   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Bioorthogonal oncometabolite ligation

, 2019
Dysregulated cellular metabolism is an emerging hallmark of cancer. Improved methods to profile aberrant metabolic activity thus have substantial applications as tools for diagnosis and understanding the biology of malignant tumors. Here we describe the utilization of a bioorthogonal ligation to fluorescently detect the TCA cycle oncometabolite ...
Chloe A, Briney, Susana, Najera, Jordan L, Meier   +2 more
openaire   +3 more sources

Rapid Photogelation of Low‐Concentration Polymer Solutions via Photodimerization of o‐Ethylnitrobenzene

Advanced Science, EarlyView.
Upon UV irradiation, flexible and tough hydrogels are formed rapidly (>0.5 s) from dilute (>0.5 wt%) solutions of o‐ethylnitrobenzene–modified PVA. At ∼1.5 wt%, the hydrogels withstand up to 10 MPa compression, remain handleable even after 200‐fold swelling.
Masaaki Okihara, Ayaka Tomoda, Kana Morishita, Toshiyuki Takagi, Kimio Sumaru   +4 more
wiley   +1 more source