Results 41 to 50 of about 17,092 (277)
Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology
Molecules, 2013 Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments.
Xiu Zhang, Yan Zhang
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IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications
Molecules, 2021 The pretargeting strategy has recently emerged in order to overcome the limitations of direct targeting, mainly in the field of radioimmunotherapy (RIT).
Maryana Handula +2 more
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Tissue Specific Labeling in Proteomics
Proteomes, 2017 Mass spectrometry-based proteomics is a powerful tool for identifying and quantifying proteins in biological samples. While it is routinely used for the characterization of simple cell line systems, the analysis of the cell specific proteome in ...
Evelyn Ramberger, Gunnar Dittmar
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A Spotlight on Viruses—Application of Click Chemistry to Visualize Virus-Cell Interactions
Molecules, 2019 The replication of a virus within its host cell involves numerous interactions between viral and cellular factors, which have to be tightly controlled in space and time.
Thorsten G. Müller +2 more
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A Genetically Encoded Isonitrile Lysine for Orthogonal Bioorthogonal Labeling Schemes
Molecules, 2021 Bioorthogonal click-reactions represent ideal means for labeling biomolecules selectively and specifically with suitable small synthetic dyes. Genetic code expansion (GCE) technology enables efficient site-selective installation of bioorthogonal handles ...
Ágnes Szatmári +8 more
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A Bioorthogonal Quadricyclane Ligation
Journal of the American Chemical Society, 2011 New additions to the bioorthogonal chemistry compendium can advance biological research by enabling multiplexed analysis of biomolecules in complex systems. Here we introduce the quadricyclane ligation, a new bioorthogonal reaction between the highly strained hydrocarbon quadricyclane and Ni bis(dithiolene) reagents.
Sletten, Ellen M., Bertozzi, Carolyn R.
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A Decade of Bioorthogonal Chemistry [PDF]
Accounts of Chemical Research, 2011 Inventing new chemical reactions is a long-standing passion of chemists, as reflected in the ever-popular field of reaction methodology. Historically, the environment in which newly crafted transformations would be performed imposed minimal limitations on reaction design; after all, solvents can be screened to find an optimal choice, temperature can be
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Direct Aromatic 18F-Labeling of Highly Reactive Tetrazines for Pretargeted Bioorthogonal PET Imaging [PDF]
, 2021 Pretargeted bioorthogonal imaging can be used to visualize and quantify slow accumulating targeting vectors with short-lived radionuclides such as fluorine-18 - the most clinically applied Positron Emission Tomography (PET) radionuclide.
Dennis, Svatunek +13 more
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The Future of Bioorthogonal Chemistry [PDF]
ACS Central Science, 2018 Bioorthogonal reactions have found widespread use in applications ranging from glycan engineering to in vivo imaging. Researchers have devised numerous reactions that can be predictably performed in a biological setting. Depending on the requirements of the intended application, one or more reactions from the available toolkit can be readily deployed ...
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