Results 61 to 70 of about 17,092 (277)
A Dual-Mechanism Targeted Bioorthogonal Prodrug Therapy
, 2023 Bioorthogonal prodrug therapies offer an intriguing two-component system that features enhanced circulating stability and controlled activation on demand.
Qingxin Yao (8676756) +8 more
core +1 more source
Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18
Molecules, 2013 The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of novel and versatile bioorthogonal conjugation techniques especially for the radiolabeling of biologically ...
Doreen Pietzsch +2 more
doaj +1 more source
Bioorthogonal Reactions in Activity-Based Protein Profiling
Molecules, 2020 Activity-based protein profiling (ABPP) is a powerful technique to label and detect active enzyme species within cell lysates, cells, or whole animals. In the last two decades, a wide variety of applications and experimental read-out techniques have been
Steven H. L. Verhelst +2 more
doaj +1 more source
Toward Realization of Bioorthogonal Chemistry in the Clinic
Topics in current chemistryIn the last decade, the use of bioorthogonal chemistry toward medical applications has increased tremendously. Besides being useful for the production of pharmaceuticals, the efficient, nontoxic reactions open possibilities for the development of ...
Kim E. de Roode +2 more
semanticscholar +1 more source
Advanced Science, EarlyView.We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang +19 more
wiley +1 more source
Bioorthogonal cyclopropenones and phosphines for biomolecule investigation
, 2023 Bioorthogonal chemistries have provided methods to investigate biomolecules in their native environments with minimal effects on cellular processes. Efforts to develop new bioorthogonal reactions have equipped researchers with powerful tools to probe ...
Dorn, Robert
core +1 more source
Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure
Advanced Science, EarlyView.Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye +6 more
wiley +1 more source
, 2017 The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway. Bioorthogonal Antigens are antigens carrying bioorthogonal groups in specific amino acid positions within the epitope region
Pawlak, J.B.
core
New bioorthogonal chemistries for multi-component detection [PDF]
, 2015 Bioorthogonal chemistries enable the selective visualization and identification of biomolecules in complex cellular environments. Significant advances in the speed and selectivity of these reactions have been reported over the past few years.
Patterson, David Michael
core +1 more source
Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics [PDF]
ChembiochemThis review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Taylor N +2 more
europepmc +2 more sources