Results 81 to 90 of about 17,092 (277)

Bioorthogonal PROTAC Prodrugs Enabled by On-Target Activation

Journal of the American Chemical Society, 2023
Although proteolysis targeting chimeras (PROTACs) have become promising therapeutic modalities, important concerns exist about the potential toxicity of the approach owning to uncontrolled degradation of proteins and undesirable ligase-mediated off ...
Mengyang Chang, F. Gao, Devin S. Pontigon, Giri Gnawali, Hang Xu, Wei Wang   +5 more
semanticscholar   +1 more source

Bioorthogonal Reactions in Bioimaging

Topics in Current Chemistry
AbstractVisualization of biomolecules in their native environment or imaging-aided understanding of more complex biomolecular processes are one of the focus areas of chemical biology research, which requires selective, often site-specific labeling of targets. This challenging task is effectively addressed by bioorthogonal chemistry tools in combination
Eszter Kozma, Péter Kele
openaire   +2 more sources

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology

Advanced Science
Bioorthogonal catalysis has revolutionized the field of chemical biology by enabling selective and controlled chemical transformations within living systems.
Yan Zhang, Qizhen Huang, Fang Lei, Wanlong Qian, Chengfeng Zhang, Qi Wang, Chaoqun Liu, Haiwei Ji, Faming Wang   +8 more
doaj   +1 more source

Development and Applications of the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) as a Bioorthogonal Reaction

Molecules, 2016
The emergence of bioorthogonal reactions has greatly broadened the scope of biomolecule labeling and detecting. Of all the bioorthogonal reactions that have been developed, the copper-catalyzed azide-alkyne cycloaddition (CuAAC) is the most widely ...
Li Li, Zhiyuan Zhang
doaj   +1 more source

Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor

Bioactive Materials, 2021
The adoptive transfer of chimeric antigen receptor-T (CAR-T) cells has shown remarkable clinical responses in hematologic malignancies. However, unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.
Hong Pan, Wenjun Li, Ze Chen, Yingmei Luo, Wei He, Mengmeng Wang, Xiaofan Tang, Huamei He, Lanlan Liu, Mingbin Zheng, Xin Jiang, Ting Yin, Ruijing Liang, Yifan Ma, Lintao Cai   +14 more
doaj   +1 more source

Supramolecular Materials and Strategies for Bioorthogonal Chemical Transformations

Chemical Reviews
Bioorthogonal reactions play a key role in controlled chemical transformations in living systems and are therefore applied to a diverse area of biological and medical applications.
Annechien A. H. Laporte, J. Reek
semanticscholar   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy

Advanced Science, EarlyView.
An orthogonal AND‐gate prodrug platform combines 390 nm near‐UV photocleavage with SA‐β‐gal activation to control payload release in senescent cells. Its modular architecture enables 4‐MU fluorescence, doxorubicin‐mediated cytotoxicity, and ARV‐771‐driven BRD4 degradation, supporting stimulus‐controlled senolytic design in cellular and organoid models.
Mengyang Chang, Kaixue Zhang, Junwei Wang, Fangchao Bi, Zhuoxin Dai, Miao Yang, Ming Liu, Huanzhi Peng, Franklin Zhang, Yuan Guo, Jigang Dai, Quanxing Liu, Wei Wang   +12 more
wiley   +1 more source

Efficient Palladium-Triggered Release of Vorinostat from a Bioorthogonal Precursor [PDF]

, 2016
Bioorthogonal uncaging strategies have recently emerged as an experimental therapeutic approach to control drug release. Herein we report a novel masking strategy that enables to modulate the metal chelating properties of hydroxamic acid groups by ...
Belén Rubio-Ruiz (1854337), Jason T. Weiss (3308859), Asier Unciti-Broceta (1324509)   +2 more
core   +2 more sources