Results 91 to 100 of about 17,092 (277)

Blocked bioorthogonal chemistry enabled switchable bioorthosome to improve liposomal drug delivery for glioblastoma therapy

Nano Research
Glioblastoma (GBM) interventions necessitate exceptional precision due to the presence of blood-brain barrier (BBB) and its intricate co-growth with neuron and glial cells.
Chao Wang, Jie Wu, Zhiran Duan, Yuqing Pan, Haijing Qu, Wei Cheng, Ning Wang, Han Chen, Xiaoli Gao, Mengqing Hou, Ying Zhang, Xiangdong Xue   +11 more
doaj   +1 more source

Bioorthogonal Decaging Reactions for Targeted Drug Activation

CHIMIA, 2018
Bioorthogonal decaging reactions are highly selective transformations which involve the cleavage of a protecting group from a molecule of interest.
Sarah Davies, Benjamin J. Stenton, Gonçalo J. L. Bernardes   +2 more
doaj   +1 more source

Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis

Nature Communications
Artificial organelles can manipulate cellular functions and introduce non-biological processes into cells. Coacervate droplets have emerged as a close analog of membraneless cellular organelles. Their biomimetic properties, such as molecular crowding and
Shou-Peng Cao, T. Ivanov, Julian Heuer, Calum T. J. Ferguson, K. Landfester, Lucas Caire da Silva   +5 more
semanticscholar   +1 more source

A Bioorthogonal Chemical Reporter of Viral Infection [PDF]

Angewandte Chemie International Edition, 2015
AbstractPathogen‐selective labeling was achieved by using the novel gemcitabine metabolite analogue 2′‐deoxy‐2′,2′‐difluoro‐5‐ethynyluridine (dF‐EdU) and click chemistry. Cells infected with Herpes Simplex Virus‐1 (HSV‐1), but not uninfected cells, exhibit nuclear staining upon the addition of dF‐EdU and a fluorescent azide. The incorporation of the dF‐
Neef Anne B., Pernot Lucile, Schreier Verena N., Scapozza Leonardo, Luedtke Nathan W.   +4 more
openaire   +8 more sources

Enzyme‐Linked Cycloaddition Assay (ELCA) for Rapid, Ultra‐Sensitive Monitoring of Secreted Sialoglycoproteins

Advanced Science, EarlyView.
Secreted glycoproteins report on cellular state faster than the cell surface, yet remain hard to measure. The Enzyme‐Linked Cycloaddition Assay (ELCA) combines metabolic azide labeling with click chemistry in an ELISA‐like microplate format, resolving sialylation changes within minutes for 1‐2 EUR per sample.
Jon Lundstrøm, Jingmei Yang, Daniel Bojar   +2 more
wiley   +1 more source

Recent Advances in Bioorthogonal Reactions

CHIMIA, 2019
The ability to selectively perform chemical reactions within living systems has transformed the field of Chemical Biology. These chemoselective processes have had a major scientific impact by enabling studies of cellular processes, producing tools for the ligations of large biomolecules, and advancing our ability to image or track small ...
Schäfer, Rebecca J.B., Aronoff, Matthew R., Wennemers, Helma   +2 more
openaire   +5 more sources

A Fluorogenic Cysteine‐Tetrapeptide Tagging Strategy for Nonperturbative Protein Labeling and Protein–Ligand Interaction Tracking

Advanced Science, EarlyView.
A compact Phe‐Cys‐Pro‐Phe (FCPF) tag and an environment‐sensitive SBD‐Cl‐derived probe form a sequence‐selective fluorogenic pair for wash‐free live‐cell protein imaging. This minimally perturbing chemistry allows flexible insertion at termini or loops, produces strong fluorescence upon local microenvironment confinement, supports FRET‐assisted ...
Xiao Wang, Xingcan Pan, Yongling Ying, Ziqian Bai, Jingming Zhang, Zhuang Shao, Jialiang Qian, Hongwei Li, Ning Zhang, Fan Yang, Yuan Liu, Xing Yang   +11 more
wiley   +1 more source

Evaluation of Pyrones in Bioorthogonal Reactions: Correlation between Structure, Reactivity, and Bioorthogonality

The Journal of Organic Chemistry
Alpha-pyrones have been used for applications ranging from total synthesis to antibiotics. However, their application as dienes in bioorthogonal reactions has not been extensively explored. In previous work, we demonstrated the promising application of ester-functionalized pyrones in bioorthogonal protein labeling.
Huang, Wei, Wen, Kangqiao, Muschitiello, Paul F., Escorihuela, Jorge, Laughlin, Scott T.   +4 more
openaire   +4 more sources

Click Chemistry in Human Cancer Research

Zhongliu Fangzhi Yanjiu
As one of the typical bioorthogonal chemistry reactions, click chemistry joins molecules similar to “Lego”. Bioorthogonal click chemistry is used to modify cancer cells, design antitumor drugs, delivery drugs, manipulate immune cells, and help ...
Baihong ZHANG, Hongyun YUE
doaj   +2 more sources

Carbohydrate‐Directed Labeling Probes for UV‐Independent Chemoproteomic Profiling of Carbohydrate–Protein Interactions

Angewandte Chemie International Edition, Volume 65, Issue 44, 26 October 2026.
Modular carbohydrate‐directed labeling probes (CDLPs) convert weak carbohydrate–protein interactions into durable covalent tags in live cells without the need for multivalency or UV irradiation. Ligand binding triggers proximity‐enabled, glycan‐releasing acyl transfer to install a click handle for protein tagging and chemoproteomic profiling.
Matthew C. Russolillo, Wariya Nirachonkul, Nora Ross, Rahul M. Hedau, Zachary Clark, Michaella J. Rekowski, Michael P. Washburn, Mark P. Farrell   +7 more
wiley   +2 more sources