Results 111 to 120 of about 17,092 (277)
Bioorthogonal Janus microparticles for photothermal and chemo‐therapy
Smart MedicineBioorthogonal chemistry, recognized as a highly efficient tool in chemical biology, has shown significant value in cancer treatment. The primary objective is to develop efficient delivery strategies to achieve enhanced bioorthogonal drug treatment for ...
Qingfei Zhang +4 more
doaj +1 more source
Senolysis Enabled by Senescent Cell-Sensitive Bioorthogonal Tetrazine Ligation
Angewandte ChemieAlthough clearance of senescent cells has been proved to slow down aging process and promote anti-cancer chemotherapy, the development of senolytics remains challenging.
Meng-Yang Chang +6 more
semanticscholar +1 more source
Synthesis of NAD analogs to develop bioorthogonal redox system
, 2013 Three new nicotinamide adenine dinucleotide (NAD) analogs were synthesized, and their characteristics as cofactors for Escherichia coli malic enzyme (ME) and its double mutant ME L310R/Q401C were analyzed.
Hou ShuHua +6 more
core +1 more source
Prodrug activation by 4,4’-bipyridine-mediated aromatic nitro reduction
Nature CommunicationsUnleashing prodrugs through nitro-reduction is a promising strategy in cancer treatment. In this study, we present a unique bioorthogonal reaction for aromatic nitro reduction, mediated by 4,4‘-bipyridine. The reaction is a rare example of organocatalyst-
Qing Wang +5 more
doaj +1 more source
Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy
Angewandte Chemie International Edition, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
1,2,4-Triazines Are Versatile Bioorthogonal Reagents
, 2016 A new class of bioorthogonal reagents, 1,2,4-triazines, is described. These scaffolds are stable in biological media and capable of robust reactivity with trans-cyclooctene (TCO).
Ryan A. Mehl (1313565) +6 more
core +1 more source
Inorganic nanoparticles as scaffolds for bioorthogonal catalysts
, 2023 Bioorthogonal transition metal catalysts (TMCs) transform therapeutically inactive molecules (pro-drugs) into active drug compounds. Inorganic nanoscaffolds protect and solubilize catalysts while offering a flexible design space for decoration with ...
Vincent M. Rotello +5 more
core +1 more source
Bioorthogonal masked acylating agents for proximity-dependent RNA labelling
Nature ChemistryRNA localization is highly regulated, with subcellular organization driving context-dependent cell physiology. Although proximity-based labelling technologies that use highly reactive radicals or carbenes provide a powerful method for unbiased mapping of
Shubhashree Pani +4 more
semanticscholar +1 more source
Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis
Journal of the American Chemical SocietyThe revolutionary impact of photoredox catalytic processes has ignited novel avenues for exploration, empowering us to delve into nature in unprecedented ways and to pioneer innovative biotechnologies for therapy and diagnosis.
Jungryun Kim +7 more
semanticscholar +1 more source
Angewandte Chemie International Edition, EarlyView.A novel trans‐cyclooctene (TCO) based noncanonical amino acid (ncAA) is reported, characterized by high hydrophilicity and remarkable stability to trans‐cis isomerization. Its incorporation via genetic code expansion into an antibody and subsequent conjugation resulted in a highly efficacious antibody‐drug conjugate (ADC).
Georgi R. Genov +4 more
wiley +1 more source