Results 121 to 130 of about 17,092 (277)
Promotion and Detection of Cell–Cell Interactions through a Bioorthogonal Approach
Journal of the American Chemical SocietyManipulation of cell–cell interactions via cell surface modification is crucial in tissue engineering and cell-based therapy. To be able to monitor intercellular interactions, it can also provide useful information for understanding how the cells ...
Evelyn Y Xue +3 more
semanticscholar +1 more source
Angewandte Chemie International Edition, EarlyView.Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt +9 more
wiley +1 more source
New bioorthogonal self-immolative linker based on the Grob fragmentation reaction [PDF]
, 2022 We have designed and synthesized a new self-immolative bioorthogonal cleavable linkerbased on the Grob fragmentation reaction that allows the controlled release of sulfonate-containing compounds such as a dansyl group under physiological conditions.
J. Héctor Busto [0000-0003-4403-4790] +11 more
core
Biomimetic N‐cyano sulfoximine–thiazole ligation for antibody–drug conjugate assembly
Bulletin of the Korean Chemical Society, EarlyView.Biomimetic N‐cyano sulfoximine–thiazole ligation is applied for the first time to antibody–drug conjugate assembly. Installation of a sulfoximine handle on trastuzumab followed by ligation with a cysteine‐functionalized payload affords model ADCs with tunable drug‐to‐antibody ratios of 2–8 under mild aqueous conditions.
Eunsil Kim +7 more
wiley +1 more source
A Bioorthogonal Precision Tool for human N-acetylglucosaminyltransferase V [PDF]
Correct elaboration of N-linked glycans in the secretory pathway of human cells is essential in physiology. Early N-glycan biosynthesis follows an assembly line principle before undergoing crucial elaboration points that feature the sequential ...
Yu, Liu +14 more
core +2 more sources
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Creation of Bioorthogonal Redox Systems Depending on Nicotinamide Flucytosine Dinucleotide
, 2011 Creation of Bioorthogonal Redox Systems Depending on Nicotinamide Flucytosine DinucleotideMany enzymes catalyzing biological redox chemistry depend on the omnipresent cofactor, nicotinamide adenine dinucleotide (NAD).
Wang, Jinxia +7 more
core +1 more source
Chemistry – A European Journal, EarlyView.Self‐assembled photocatalyst Ru(Ada‐bpy)(bpy)2⊂HACD targets cancer cells and catalyzes the prodrug to drug upon exposure to visible light, providing spatially and temporally control in cancer cells. This strategy achieves efficient, controllable, and targeted activation of prodrugs within cancer cells, laying the foundation of effectively reducing the ...
Jianghua Liu +3 more
wiley +1 more source
Development of Blue‐to‐Near‐Infrared rTCO–Caged Fluorogenic Probes for Click‐to‐Release Monitoring
Chemistry – A European Journal, EarlyView.A series of fluorogenic rTCO‐caged click‐to‐release probes was prepared and evaluated both in a cuvette and in live cells. Some of the probes exhibited significant turn‐on and efficient fluorophore release spanning the blue‐to‐NIR region. A significant difference in the performance of the compounds in live cells was observed, highlighting the need for ...
Marek Chovanec +4 more
wiley +1 more source
Photocatalysis‐Triggered Click Reactions and Applications
European Journal of Organic Chemistry, EarlyView.Photoclick chemistry offers broad applications ranging from materials science to bioconjugation, with precise spatiotemporal control over click reactions. Initially limited to UV activation, recent advances have extended photoclick processes to the visible and NIR regions thanks to the photocatalysis.
Margaux Walter +2 more
wiley +1 more source