Results 141 to 150 of about 17,092 (277)

Enhanced through‐bond energy transfer‐based bioorthogonal probe enables catalytic‐amplified and sensitive detection of microRNA‐21 for clinical lung cancer diagnosis

Smart Molecules, EarlyView.
Inverse Diels‐Alder Cycloaddition Reaction was developed for ultrasensitive miR‐21 detection. Based on the enhanced Through‐Bond Energy Transfer and catalytic amplification, it shows a detection limit of 3.58 × 10−18 M and 100 aM–100 nM linear range. It enables high‐contrast cell/tissue imaging and distinguishes lung cancer patients in serum, promising
Yikun Li, Fuping Han, Haiqiao Huang, Danhong Zhou, Saran Long, Wen Sun, Jianjun Du, Jiangli Fan, Jing Ning, Chong Peng, Xiaojun Peng   +10 more
wiley   +1 more source

Imaging Drug Uptake by Bioorthogonal Stimulated Raman Scattering Microscopy

, 2017
Stimulated Raman scattering (SRS) microscopy in tandem with bioorthogonal Raman labelling strategies is set to revolutionise the direct visualisation of intracellular drug uptake.
Lee, Martin, Serrels, Alan, Brunton, Valerie G, Hulme, Alison, Tipping, William J   +4 more
core   +1 more source

In‐Gel Generated Palladium Nanostructures as Bioorthogonal Uncaging Reactors

Advanced NanoBiomed Research
In the quest to alleviate the severe side effects of chemotherapy, a promising approach is through prodrugs, an inactivate form of the drug that is administered systemically but activated locally.
Aisling McGuigan, Víctor Sebastián, Asier Unciti‐Broceta, Jesús Santamaría, Ferry Melchels   +4 more
doaj   +1 more source

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Smart Molecules, EarlyView.
MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag, Subhasis Banerjee, Sabyasachi Banerjee, Sourav De, S. K. Ashok Kumar, Yan‐Jye Shyong, Subhankar Mukhopadhyay   +6 more
wiley   +1 more source

Sydnthiones are versatile bioorthogonal hydrogen sulfide donors

Nature Communications
Hydrogen sulfide (H2S) is an important endogenous gasotransmitter, but the bioorthogonal reaction triggered H2S donors are still rare. Here we show one type of bioorthogonal H2S donors, sydnthiones (1,2,3-oxadiazol-3-ium-5-thiolate derivatives), which ...
Wenyuan Xu, Cheng Tang, Ruohan Zhao, Yajun Wang, Hongyun Jiao, Han Ang, Yinghan Chen, Xin Wang, Yong Liang   +8 more
doaj   +1 more source

Precision delivery of estrogen receptor antagonists using bioorthogonal chemistry-based intelligent nanocarriers to overcome cervical cancer drug resistance

Materials Today Bio
Cervical cancer remains a significant health burden among women worldwide, with drug resistance posing a major obstacle to effective treatment strategies.
Xue Yang, Yang Gu
doaj   +1 more source

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Bioorthogonal Enzymatic Activation of Caged Compounds

, 2015
Engineered cytochrome P450 monooxygenase variants are reported as highly active and selective catalysts for the bioorthogonal uncaging of propargylic and benzylic ether protected substrates, including uncaging in living E. coli.
Kraling, K., Katja Kräling, Ritter, C., Hoebenreich, S., Richard Lonsdale, Nathalie Nett, Meggers, E., Manfred T. Reetz, Cornelia Ritter, Graumann, P., Carlos G. Acevedo‐Rocha, Sabrina Hoebenreich, Nett, N., Dempwolff, F., Acevedo-Rocha, C., Reetz, M., Peter L. Graumann, Lonsdale, R., Felix Dempwolff, Eric Meggers   +19 more
core   +1 more source

A catalyst-free bioorthogonal reaction for malononitrile addition to azodicarboxylates

Nature Communications
Developing bioorthogonal reactions that enable fundamental exploration of biological processes remains a key pursuit of chemical biology. We report here malononitrile addition to azodicarboxylate as a distinct class of catalyst-free bioorthogonal ...
Honggui Huang, Xingyu Liu, Qianqian Qi, Hannan Chen, Haiyan Zhang, Kaisong Zhang, Xinyan Xu, Yunting Zhao, Xiang Zhou, Wenbo Liu, Tian Tian   +10 more
doaj   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source