Results 151 to 160 of about 17,092 (277)
TADF‐Active Tetrazole Luminophores for Visible‐Light Functionalization of Nanoparticles and Surfaces
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.A series of tetrazoles are reported that undergo 1,3‐dipolar cycloadditions with alkene and alkyne substrates, generating (dihydro)pyrazole products that exhibit thermally activated delayed fluorescence (TADF). The “photo‐click” reactivity of these tetrazoles is leveraged to functionalize nanoparticles and surfaces with TADF‐active chromophores ...
Ryoga Hojo +11 more
wiley +2 more sources
Click Chemistry and Bioorthogonal Reaction for Aggregation‐Induced Emission Bioconjugates
AggregateThe resulting product of biocoupling is a bioconjugate, typically formed by linking molecules to proteins, oligosaccharides, nucleic acids, or synthetic polymers.
Xinzhe Yang +3 more
doaj +1 more source
Angewandte ChemieBioorthogonal reactions that enable switching molecular functions by breaking chemical bonds have gained prominence, with the tetrazine-mediated cleavage of trans-cyclooctene caged compounds (click-to-release) being particularly noteworthy for its high ...
Michal Rahm +12 more
semanticscholar +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 6, December 2026.ABSTRACT We previously developed nanobodies acting as positive allosteric modulators (PAMs) of the calcium‐sensing receptor (CaSR). Here, we sought to develop more potent CaSR modulators by creating bivalent nanobody constructs using ‘tail‐to‐head’ peptide‐linker conjugation.
Mahdis Nabipour +5 more
wiley +1 more source
Development and application of bond cleavage reactions in bioorthogonal chemistry
, 2016 Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as an unprecedented technique to dissect native biological processes through chemistry-enabled strategies. However, current concepts of bioorthogonal chemistry have
Li, Jie, Chen, Peng R.
core +1 more source
A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation
Angewandte Chemie International Edition, Volume 65, Issue 45, 2 November 2026.The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf +4 more
wiley +1 more source
Reactions“Click” cycloadditions offer effective pathways for the modifications of supramolecular structures, polymers, and nanomaterials. These reactions include bioorthogonal mechanisms that do not interfere with the biological processes, providing a type of ...
Irene Lepori +6 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy +7 more
wiley +2 more sources
Nature CommunicationsDynamic and programmable control of therapeutic delivery is a long-standing goal in medicine. Iontronic devices offer precise electronic control over the dosage of bioactive molecules, yet their use has been confined to charged, low-molecular-weight ...
Sebastian Hecko +18 more
doaj +1 more source
Strain-Promoted Bioorthogonal Chemistry
Strain-promoted bioorthogonal reactions, driven by cycloalkynes and cycloalkenes, have become indispensable in chemical biology. These strained chemical tools enable selective bioorthogonal ligations and bond-cleavage reactions, supporting research and ...
Schiefer, Andrea +2 more
core +1 more source