Results 21 to 30 of about 17,092 (277)
A Spatially Distributed Microneedle System for Bioorthogonal T Cell‐Guided Cancer Therapy
Advanced ScienceChimeric antigen receptor (CAR)‐T cell therapy represents a promising strategy for cancer treatment. However, the diversity of solid tumor antigens and the poor infiltration of CAR‐T cells significantly hinder the efficacy of CAR‐T therapies against ...
Lanya Li +11 more
doaj +2 more sources
Development of Bioorthogonal Reactions and Their Applications in Bioconjugation
Molecules, 2015 Biomolecule labeling using chemical probes with specific biological activities has played important roles for the elucidation of complicated biological processes.
Mengmeng Zheng +4 more
doaj +2 more sources
Nature CommunicationsThe prodrug design strategy offers a potent solution for improving therapeutic index and expanding drug targets. However, current prodrug activation designs are mainly responsive to endogenous stimuli, resulting in unintended drug release and systemic ...
Xinyu He +7 more
doaj +2 more sources
Membrane-Targeted Nanoparticles for Neuronal Photomodulation. [PDF]
Adv Sci (Weinh)Immobilizing gold nanoparticles on the neural interface using a bioorthogonal approach generates localized heat upon exposure to near‐infrared light, temporarily inhibiting primary neuronal activity without damaging the cells. This precise placement and retention of nanoparticles at the cell membrane expand the strategies for non‐invasive neural ...
Escobar A +9 more
europepmc +2 more sources
Site-Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids. [PDF]
Angew Chem Int Ed EnglGenetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Sarkar R, Joshi M, Chatterjee A.
europepmc +3 more sources
In Situ Bioorthogonal Synthesis of PROTACs via Dual-Responsive Cleavage for Synergistic Photo-Immunotherapy. [PDF]
Adv Sci (Weinh)A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Jian S +14 more
europepmc +2 more sources
Characterization of an N-Allylglyoxylamide Based Bioorthogonal Nitrone Trap [PDF]
, 2023 Aldehydes are attractive bioorthogonal coupling partners. The ease of manipulation of aldehydes and their orthogonality to other classes of bioorthogonal reactions has inspired the exploration of chemistries which generate irreversible conjugates ...
Hunter, Clark +7 more
core +2 more sources
Bioorthogonal photocatalytic decaging-enabled spatiotemporal proteomics [PDF]
, 2021 Spatiotemporally resolved dissection of subcellular proteome is crucial to our understanding of cellular functions in health and disease.
Xiao, Xie +7 more
core +2 more sources
Data-Driven Identification of Metal-free Orthogonal Bioorthogonal Cycloaddition Pairs [PDF]
, 2022 Mutually orthogonal bioorthogonal reactions are a thriving area of research in chemical biology. Here we present a predictive-driven approach to identify mutually orthogonal pairs among two bioorthogonal reactions: the metal-free 1,3-dipolar ...
Jaime, A. S. Coelho +1 more
core +2 more sources
Bioorthogonal Chemistry and Its Applications [PDF]
Bioconjugate Chemistry, 2021 Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms. In this review, we summarize the most common reactions used in bioorthogonal methods, their relative advantages and disadvantages, and their frequency of occurrence in the published literature.
Robert E. Bird +3 more
openaire +2 more sources