Isomeric triazines exhibit unique profiles of bioorthogonal reactivity. [PDF]
, 2019 Expanding the scope of bioorthogonal reactivity requires access to new and mutually compatible reagents. We report here that 1,2,4-triazines can be tuned to exhibit unique reaction profiles with biocompatible strained alkenes and alkynes.
Briggs, Jeffrey S +9 more
core
Fluorogenic Coumarins Activated via Bioorthogonal Reaction
The Journal of Organic ChemistryFluorogenic bioorthogonal reagents enable facile detection in complex environments. While useful for real-time imaging, few such probes are available. Existing tools also exploit similar mechanisms for signal turn-on, precluding multiplexed applications.
Halley M. Lin-Jones +4 more
openaire +1 more source
Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole [PDF]
, 2016 2-Cyanobenzothiazoles (CBTs) are useful building blocks for: 1) luciferin derivatives for bioluminescent imaging; and 2) handles for bioorthogonal ligations.
Bayana, ME +5 more
core +2 more sources
Angewandte Chemie International Edition, EarlyView.Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe +7 more
wiley +1 more source
Facile, productive, and cost-effective synthesis of a novel tetrazine-based iron oxide nanoparticle for targeted image contrast agents and nanomedicines [PDF]
, 2018 We have developed an operationally simple, time, and cost-effective protocol to produce a novel tetrazine-based iron oxide nanoparticle using commercially available and inexpensive materials.
A Kuzmin +24 more
core +3 more sources
A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase
Angewandte Chemie International Edition, EarlyView.The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne +22 more
wiley +1 more source
Surface Modification of Melt Extruded Poly(ε-caprolactone) Nanofibers: Toward a New Scalable Biomaterial Scaffold. [PDF]
, 2014 A photochemical modification of melt-extruded polymeric nanofibers is described. A bioorthogonal functional group is used to decorate fibers made exclusively from commodity polymers, covalently attach fluorophores and peptides, and direct cell growth ...
Baer, Eric +5 more
core +2 more sources
Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi‐Target Imaging [PDF]
Angewandte Chemie, 2011 Mutually orthogonal tetrazine–transcyclooctene and azide–cyclooctyne cycloaddition reactions were used simultaneously for the bioorthogonal labeling of two different live cell populations in the same culture. These small-molecule probes show good chemical reactivity and can be readily incorporated into biological systems.
Mark R, Karver +2 more
openaire +2 more sources
Direct Intracellular Delivery of Cell Impermeable Probes of Protein Glycosylation Using Nanostraws [PDF]
, 2017 Bioorthogonal chemistry is an effective tool for elucidating metabolic pathways and measuring cellular activity, yet its use is currently limited by the difficulty of getting probes past the cell membrane and into the cytoplasm, especially if more ...
Cao, Yuhong +4 more
core
Cycloadditions of cyclohexynes and cyclopentyne. [PDF]
, 2014 We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described.
Garg, Neil K +4 more
core +2 more sources