Kinugasa Reactions in Water: From Green Chemistry to Bioorthogonal Labelling [PDF]
Molecules, 2015 The Kinugasa reaction has become an efficient method for the direct synthesis of β-lactams from substituted nitrones and copper(I) acetylides. In recent years, the reaction scope has been expanded to include the use of water as the solvent, and with micelle-promoted [3+2] cycloadditions followed by rearrangement furnishing high yields of β-lactams. The
Mariya, Chigrinova +5 more
openaire +4 more sources
Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling
Angewandte Chemie International Edition, EarlyView.Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl +1 more
wiley +1 more source
Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment [PDF]
, 2014 The rapidly increasing interest in the synthesis of antibody–drug conjugates as powerful targeted anticancer agents demonstrates the growing appreciation of the power of antibodies and antibody fragments as highly selective targeting moieties.
Boyle, Ross W. +6 more
core +1 more source
Visualizing in situ translational activity for identifying and sorting slow-growing archaeal−bacterial consortia [PDF]
, 2016 To understand the biogeochemical roles of microorganisms in the environment, it is important to determine when and under which conditions they are metabolically active.
Connon, Stephanie A. +5 more
core +2 more sources
Genetic code expansion for chemosensing and chemical actuation of biological functions
Bulletin of the Korean Chemical Society, EarlyView.Genetic code expansion (GCE) broadens the chemical repertoire for precise control of protein function in biological systems. This review highlights GCE‐based sensing and actuating systems that operate through selective interactions between noncanonical amino acids and chemical triggers.
Jieun Bae, Dong‐Hyun Kim, Minseob Koh
wiley +1 more source
Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis [PDF]
, 2014 The need for post-synthetic modifications and reactive prosthetic groups has long been a limiting factor in the synthesis and study of peptidic and peptidomimetic imaging agents.
Emmetiere, Fabien +5 more
core +1 more source
Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy
BMEMat, EarlyView.This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma +9 more
wiley +1 more source
Engineering cell surfaces by covalent grafting of synthetic polymers to metabolically-labeled glycans [PDF]
, 2018 Re-engineering mammalian cell surfaces enables modulation of their phenotype, function, and interactions with external markers and may find application in cell-based therapies.
Bailey, Trisha L. +3 more
core +2 more sources
BMEMat, EarlyView.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle [PDF]
, 2016 Through the genetic incorporation of a single phenyl azide group into superfolder GFP (sfGFP) at residue 148 we provide a molecular description of how this highly versatile chemical handle can be used to positively switch protein function in vitro and in
Hartley, Andrew M. +4 more
core +3 more sources