Results 71 to 80 of about 5,912 (181)

Artificial intelligence and machine learning-guided bio-orthogonal engineering of smart soft polymeric nanocarriers for precision drug delivery and translational nanomedicine

Frontiers in Soft Matter
Soft polymeric nanocarriers provide programmable platforms for precision drug delivery, yet their rational design remains constrained by complex relationships among polymer chemistry, soft-matter properties, formulation, and biological performance ...
Suman Basak, Suman Basak
doaj   +1 more source

A Dansyl Amide N‐Oxide Fluorogenic Probe Based on a Bioorthogonal Decaging Reaction

ChemistryOpen, 2021
A smart fluorescence “turn‐on” probe which contained a dansyl amide fluorophore and an N‐oxide group was designed based on the bioorthogonal decaging reaction between N‐oxide and the boron reagent. The reaction proceeds in a rapid kinetics (k2=57.1±2.5 m−
Dr. Hong Yang, Dr. Yongcheng Wang, Xiang Li, Yu Teng, Dr. Yulin Tian   +4 more
doaj   +1 more source

Specific Modulation of Protein Activity by Using a Bioorthogonal Reaction [PDF]

ChemBioChem, 2014
Abstract Unnatural amino acids with bioorthogonal reactive groups have the potential to provide a rapid and specific mechanism for covalently inhibiting a protein of interest. Here, we use mutagenesis to insert an unnatural amino acid containing an azide group (Z) into the target protein at positions such that a ...
John B, Warner, Anand K, Muthusamy, E James, Petersson   +2 more
openaire   +2 more sources

Click Chemistry and Bioorthogonal Reaction for Aggregation‐Induced Emission Bioconjugates

Aggregate
The resulting product of biocoupling is a bioconjugate, typically formed by linking molecules to proteins, oligosaccharides, nucleic acids, or synthetic polymers.
Xinzhe Yang, Miaomiao Kang, Dong Wang, Ben Zhong Tang   +3 more
doaj   +1 more source

Rapid and Specific Cell-Surface Anchoring of Gold Nanostars for Photoacoustic BMSC Imaging

BIO Integration
Background: Bone marrow mesenchymal stem cell (BMSC) therapy holds great promise for regenerative medicine, but its clinical translation is hindered by the lack of non-invasive, real-time methods to track transplanted cell fate in vivo.
Renhao Xu, Yanmei Cai, Xiaobin Dong, Xuezhi Wang, Wenyi Zheng, Ning Zhang, Yanni He, Hongmei Liu   +7 more
doaj   +1 more source

Toward Ideal Proximity‐Driven Reactions in Chemical Biology [PDF]

Chembiochem
Building on established principles of molecular templation, this perspective explores how molecular recognition can control chemical reactivity in space and time and outlines the design principles of an ideal proximity‐driven reaction for chemical biology.
Schauenburg D.
europepmc   +2 more sources

Click-Triggered Bioorthogonal Bond-Cleavage Reactions

Topics in Current Chemistry
Abstract Bioorthogonal bond-cleavage reactions have evolved into powerful tools for chemical biology, representing a promising strategy for achieving controlled release of molecules under physiologically relevant conditions, even in living organisms.
Patrick Keppel, Sebastian Hecko, Hannes Mikula   +2 more
openaire   +2 more sources

Recent Advances in Bioorthogonal Click Chemistry for Efficient Synthesis of Radiotracers and Radiopharmaceuticals

Molecules, 2019
In recent years, several catalyst-free site-specific reactions have been investigated for the efficient conjugation of biomolecules, nanomaterials, and living cells.
Sajid Mushtaq, Seong-Jae Yun, Jongho Jeon   +2 more
doaj   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Synthesis of a Stable Hydrophilic trans‐Cyclooctene Amino Acid Unlocks Fast Bioorthogonal Click Chemistry for the Generation of Antibody‐Drug Conjugates by Genetic Code Expansion

Angewandte Chemie International Edition, EarlyView.
A novel trans‐cyclooctene (TCO) based noncanonical amino acid (ncAA) is reported, characterized by high hydrophilicity and remarkable stability to trans‐cis isomerization. Its incorporation via genetic code expansion into an antibody and subsequent conjugation resulted in a highly efficacious antibody‐drug conjugate (ADC).
Georgi R. Genov, Dina Osmanović, Ines Bašić, Christine Koehler, Paul F. Sauter   +4 more
wiley   +1 more source