Results 81 to 90 of about 7,204 (227)
Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18
Molecules, 2013 The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of novel and versatile bioorthogonal conjugation techniques especially for the radiolabeling of biologically ...
Doreen Pietzsch +2 more
doaj +1 more source
Development of Blue‐to‐Near‐Infrared rTCO–Caged Fluorogenic Probes for Click‐to‐Release Monitoring
Chemistry – A European Journal, EarlyView.A series of fluorogenic rTCO‐caged click‐to‐release probes was prepared and evaluated both in a cuvette and in live cells. Some of the probes exhibited significant turn‐on and efficient fluorophore release spanning the blue‐to‐NIR region. A significant difference in the performance of the compounds in live cells was observed, highlighting the need for ...
Marek Chovanec +4 more
wiley +1 more source
Synthesis and Structure of Dimethyl 3,6-Diphenyl-1,2- Dihydro-1,2,4,5-Tetrazine-1,2-Dicarboxylate
, 2010 Dimethyl 3,6-diphenyl-1,2-dihydro-1,2,4,5-tetrazine-1,2-dicarboxylate was prepared from methyl chloroformate and 3,6-diphenyl-1,2(or 1,4)-dihydro-1,2,4,5-tetrazine and its structure elucidated by X-ray analysis.
Xiao-Jing Lu, Guo-Wu Rao, Wei-Xiao Hu
core +1 more source
AggregateFluorescence imaging, a key technique in biological research, frequently utilizes fluorogenic probes for precise imaging in living systems. Tetrazine is an effective emission quencher in fluorogenic probe designs, which can be selectively damaged upon ...
Shinsuke Segawa +12 more
doaj +1 more source
Photocatalysis‐Triggered Click Reactions and Applications
European Journal of Organic Chemistry, EarlyView.Photoclick chemistry offers broad applications ranging from materials science to bioconjugation, with precise spatiotemporal control over click reactions. Initially limited to UV activation, recent advances have extended photoclick processes to the visible and NIR regions thanks to the photocatalysis.
Margaux Walter +2 more
wiley +1 more source
Improved synthesis and properties of 3,6-diamino-1,2,4,5-tetrazine and 3,6-dihydrazino-1,2,4,5-tetrazine [PDF]
, 1989 The chemical preparation of: (a) 3,6-diamino-1,2,4,5-tetrazine and (b) 3,6-dihydrazino-1,2,4,5-tetrazine is described. The explosive performance of the compounds was calculated with the BKW code.
Ott, Donald G. +3 more
core
MoleculesThis review summarises the possible applications and basic methodologies for the synthesis of six-membered polyazo heterocycles, namely, diazines, triazines, and tetrazines.
Elena A. Gyrgenova +2 more
doaj +1 more source
N1,N4,3,6-Tetramethyl-1,2,4,5-tetrazine-1,4-dicarboxamide
Acta Crystallographica Section E, 2012 The asymmetric unit of the title compound, C8H14N6O2, contains two independent molecules. In one molecule, the amide-substituted N atoms of the tetrazine ring deviate from the plane [maximum deviation = 0.028 (1) Å] through ...
Na-Bo Sun, Guo-Wu Rao, Qun Shen
doaj +1 more source
SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting
Medicinal Research Reviews, EarlyView.ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama +2 more
wiley +1 more source
Polymer Chemistry, 2020 Tetrazine- and trans -cyclooctene-functionalised polypeptides and polypetoids were prepared by ring-opening polymerisation of N -carboxyanhydrides using the respective functional initiators and shown to react in fast bioorthogonal tetrazine ligations.
Kerstin Johann +8 more
openaire +4 more sources