Results 101 to 110 of about 7,204 (227)

[4 + 2]-Cycloaddition with Inverse Electron Demand: Reaction of 3-Vinylindoles with Dimethyl 1,2,4,5-Tetrazine-3,6- dicarboxylate

CHIMIA, 1987
The 1'-substituted 3-vinylindoles 1a and 1b react locoselectively with the tetrazine 2 to form the corresponding 1,4-dihydro-1,2-diazines. The 2'-methoxy-substituted compound 1c yields the 4-(indol-3-yl)-substituted 1,2-diazine 5 on reaction with the ...
Ulf Pindur, Ludwig Pfeuffer
doaj   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

Efficient F Labeling of Cysteine-Containing Peptides and Proteins Using Tetrazine–-Cyclooctene Ligation

Molecular Imaging, 2013
18 F positron emission tomography (PET) has a number of attributes that make it clinically attractive, including nearly 100% positron efficiency, very high specific radioactivity, and a short half-life of ≈ 110 minutes. However, the short half-life of 18
Shuanglong Liu, Matthew Hassink, Ramajeyam Selvaraj, Li-Peng Yap, Ryan Park, Hui Wang, Xiaoyuan Chen, Joseph M. Fox, Zibo Li, Peter S. Conti   +9 more
doaj   +1 more source

Toward Ideal Proximity‐Driven Reactions in Chemical Biology

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
Building on established principles of molecular templation, this perspective explores how molecular recognition can control chemical reactivity in space and time and outlines the design principles of an ideal proximity‐driven reaction for chemical biology.
Dominik Schauenburg
wiley   +1 more source

An air-stable bisboron complex: a practical bidentate Lewis acid catalyst

Beilstein Journal of Organic Chemistry, 2018
We report an air-stable bisboron complex as an efficient catalyst for the inverse electron-demand Diels–Alder (IEDDA) reaction of 1,2-diazine as well as 1,2,4,5-tetrazine.
Longcheng Hong, Sebastian Ahles, Andreas H. Heindl, Gastelle Tiétcha, Andrey Petrov, Zhenpin Lu, Christian Logemann, Hermann A. Wegner   +7 more
doaj   +1 more source

catena-Poly[[[(triphenylphosphane)copper(I)]-di-μ-iodido-[(triphenylphosphane)copper(I)]-μ-[3,6-bis(4-pyridyl)-1,2,4,5-tetrazine]] acetonitrile disolvate]

Acta Crystallographica Section E, 2010
The title compound, {[Cu2I2(C12H8N6)(C18H15P)2]·2CH3CN}n, contains centrosymmetric dinuclear Cu2I2(PPh3)2 units bridged by 3,6-bis(4-pyridyl)-1,2,4,5-tetrazine ligands lying also across crystallographic inversion centers, giving a chain ...
Jinfang Zhang
doaj   +1 more source

Decoding Heptazine Architectures: From Molecular Association to Structural Insight

Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.
A comprehensive study (NMR and theoretical) of three novel heptazine derivatives that self‐assemble into dimers has been conducted, highlighting their versatility as a platform for multifunctional supramolecular and optoelectronic materials. ABSTRACT Heptazine (Hpz) derivatives display remarkable supramolecular organization governed by noncovalent ...
Silvia del Moral, Daniel Barrena‐Espés, Julen Munarriz, Matthias Lehmann, Pilar Romero, José Luis Serrano   +5 more
wiley   +1 more source

Towards novel 1,2,4,5-Tetrazine mediated peptide macrocyclisations [PDF]

, 2016
Interest in linear peptides and peptidomimetics experienced rapid growth within the pharmaceutical industry due to their ability to disrupt protein-protein interactions; and their ability to modulate protein function by allosteric regulation and ...
Harwood, Iain David
core  

Alkene–Tetrazine ligation for imaging cellular DNA

, 2014
5-Vinyl-2'-deoxyuridine (VdU) is the first reported metabolic probe for cellular DNA synthesis that can be visualized by using an inverse electron demand Diels-Alder reaction with a fluorescent tetrazine.
Luedtke, Nathan W, Rieder, U, Rieder U, Luedtke NW   +3 more
core   +1 more source

Investigation of Proteome-Tetrazine Reactivity for a Highly Selective Tetrazine Ligation in Live Cells

ACS Central Science
Tetrazine has been widely used in bio-orthogonal click chemistry for diverse biological applications due to its short reaction time and excellent bio-orthogonality. For efficient click reaction, the stability of tetrazine in physiological conditions is one of the key issues in biological applications.
Junyoung Park, Juhee Hahm, Junhyeong Yim, Hyelim Lee, Hwan Min Hwang, Soyeon Lee, Ju-Young Park, Arun Velladurai, Jagadeesh Kumar Gangasani, Hana Cho, Hankum Park, Minju Lee, Jeehee Lee, Hyunuk Eom, Woon Ju Song, Sanghee Lee, Eunha Kim, Jongmin Park   +17 more
openaire   +3 more sources