Results 101 to 110 of about 9,278 (213)

Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection. [PDF]

, 2019
"Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood ...
Anton, Peter A, Deming, Timothy, Elliott, Julie, Fulcher, Jennifer A, Ibarrondo, F Javier, Kickhoefer, Valerie A, Maynard, Heather D, Mrazek, Jan, Rome, Leonard H, Tamshen, Kyle, Wollenberg, Alexander L, Yang, Otto O   +11 more
core  

Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics [PDF]

, 2015
Antibodies are currently the fastest-growing class of therapeutics. Although naked antibodies have proven valuable as pharmaceutical agents, they have some limitations, such as low tissue penetration and a long circulatory half-life.
Boellaard, Cortez-Retamozo, De Genst, De Meyer, Dijkers, Holliger, Lipson, Olafsen, Rashidian, Rashidian, Rashidian, Schellekens, Simpson, Tavare, Vugmeyster   +14 more
core   +1 more source

[4 + 2]-Cycloaddition with Inverse Electron Demand: Reaction of 3-Vinylindoles with Dimethyl 1,2,4,5-Tetrazine-3,6- dicarboxylate

CHIMIA, 1987
The 1'-substituted 3-vinylindoles 1a and 1b react locoselectively with the tetrazine 2 to form the corresponding 1,4-dihydro-1,2-diazines. The 2'-methoxy-substituted compound 1c yields the 4-(indol-3-yl)-substituted 1,2-diazine 5 on reaction with the ...
Ulf Pindur, Ludwig Pfeuffer
doaj   +1 more source

Bioorthogonal Double-Fluorogenic Siliconrhodamine Probes for Intracellular Superresolution Microscopy [PDF]

, 2017
A series of double-fluorogenic siliconrhodamine probes were synthesized. These tetrazine-functionalized, membrane-permeable labels allowed site-specific bioorthogonal tagging of genetically manipulated intracellular proteins and subsequent imaging ...
Estrada Girona, G., Kele, Péter, Kozma, E., Lemke, E. A., Paci, G.   +4 more
core   +1 more source

Efficient F Labeling of Cysteine-Containing Peptides and Proteins Using Tetrazine–-Cyclooctene Ligation

Molecular Imaging, 2013
18 F positron emission tomography (PET) has a number of attributes that make it clinically attractive, including nearly 100% positron efficiency, very high specific radioactivity, and a short half-life of ≈ 110 minutes. However, the short half-life of 18
Shuanglong Liu, Matthew Hassink, Ramajeyam Selvaraj, Li-Peng Yap, Ryan Park, Hui Wang, Xiaoyuan Chen, Joseph M. Fox, Zibo Li, Peter S. Conti   +9 more
doaj   +1 more source

catena-Poly[[[(triphenylphosphane)copper(I)]-di-μ-iodido-[(triphenylphosphane)copper(I)]-μ-[3,6-bis(4-pyridyl)-1,2,4,5-tetrazine]] acetonitrile disolvate]

Acta Crystallographica Section E, 2010
The title compound, {[Cu2I2(C12H8N6)(C18H15P)2]·2CH3CN}n, contains centrosymmetric dinuclear Cu2I2(PPh3)2 units bridged by 3,6-bis(4-pyridyl)-1,2,4,5-tetrazine ligands lying also across crystallographic inversion centers, giving a chain ...
Jinfang Zhang
doaj   +1 more source

Bio-orthogonal Fluorescent Labelling of Biopolymers through Inverse-Electron-Demand Diels–Alder Reactions [PDF]

, 2017
Bio-ort hogona llabellin gschemes based on inverse-elec tron- deman dDiels–Ald er (IEDDA) cycloa ddition have attracted much attention in chem ical biology recently .The appeal ing features of this reactio n, such as the fast ...
Agard, Agarwal, Asare-Okai, Beatty, Besanceney-Webler, Blackman, Blizzard, Boger, Boger, Bond, Borrmann, Bußkamp, Carboni, Carlson, Chin, Cole, Cserép, Cserép, Darko, Dawson, Denk, Denk, Devaraj, Devaraj, Devaraj, Dieterich, Doll, Dommerholt, Domnick, Dube, Eggert, Eising, Elliott, Engelsma, Erdmann, Evans, Fan, Hoffmann, Jung, Kaya, Kimmerlin, Knall, Knorr, Kozma, Kurra, Lang, Lang, Lang, Lee, Lemke, Li, Li, Liang, Link, Liu, Liu, Lukinavičius, Mackiewicz, Meezan, Meimetis, Merkel, Neumann, Neumann-Staubitz, Nichols, Niederwieser, Nikić, Nikić, Noren, Patterson, Patterson, Patterson, Peng, Plass, Plass, Prescher, Prokhorov, Pyka, Ramil, Ren, Rieder, Royzen, Sauer, Saxon, Schoch, Schoch, Schoch, Seitchik, Sletten, Soriano del Amo, Späte, Späte, Späte, Späte, Stairs, Taylor, Uttamapinant, Versteegen, Wagner, Wainman, Wan, Wang, Wang, Wu, Wu, Wu, Yanagisawa, Yang, Yang, Yu, Zeglis, Šečkutė   +110 more
core   +1 more source

Tuning of the Optical Properties of Cis‐ and Trans‐Bis‐Tetrazo[1,2‐b]indazoles Guided by Predictive DFT: An Isomer Story

Advanced Optical Materials, Volume 14, Issue 16, 24 April 2026.
We report the synthesis and properties of novel N‐rich polyaromatics (cis‐ and trans tetrazo[1,2‐b]indazoles). Following a density functinal theory (DFT)‐guided molecular engineering, we introduced substituents at various positions. The effect of these substituents on the spectroscopic/redox properties was fully rationalized by DFT.
Louis Lemetayer, Guillaume Le Breton, Asmae Bousfiha, Marie Cordier, Yoann Rousselin, Hélène Cattey, Jean‐Cyrille Hierso, Julien Roger, Paul Fleurat‐Lessard, Pierre‐Antoine Bouit   +9 more
wiley   +1 more source

An air-stable bisboron complex: a practical bidentate Lewis acid catalyst

Beilstein Journal of Organic Chemistry, 2018
We report an air-stable bisboron complex as an efficient catalyst for the inverse electron-demand Diels–Alder (IEDDA) reaction of 1,2-diazine as well as 1,2,4,5-tetrazine.
Longcheng Hong, Sebastian Ahles, Andreas H. Heindl, Gastelle Tiétcha, Andrey Petrov, Zhenpin Lu, Christian Logemann, Hermann A. Wegner   +7 more
doaj   +1 more source

N,N’‐Dialkylated Oxo‐Verdazyl Radicals as Bipolar Organic Molecules for Symmetric Redox Flow Batteries

ChemElectroChem, Volume 13, Issue 7, 1 April 2026.
In this work, N,N’‐dialkylated oxo‐verdazyl radicals have been studied in redox flow batteries for the first time. Investigation of the degradation led to the identification of a decomposition product. By that, the molecular design and the cycling performance could be improved.
Elena S. Horst, Karin Sowa, Lena Lezius, Nick Fehlings, Constantin Daniliuc, Sascha Nowak, Mariano Grünebaum, Martin Winter, Armido Studer   +8 more
wiley   +1 more source