Results 51 to 60 of about 7,204 (227)

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Tetrazine‐Responsive Self‐immolative Linkers [PDF]

ChemBioChem, 2016
AbstractMolecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled
Neumann, Kevin, Jain, Sarthak, Gambardella, Alessia, Walker, Sarah E., Valero, Elsa, Lilienkampf, Annamaria, Bradley, Mark   +6 more
openaire   +5 more sources

Total Synthesis of Amaryllidaceae Alkaloids Utilizing Sequential Intramolecular Heterocyclic Azadiene Diels−Alder Reactions of an Unsymmetrical 1,2,4,5-Tetrazine

, 2016
Convergent total syntheses of anhydrolycorinone, hippadine, and anhydrolycorinium chloride are detailed, enlisting sequential inverse electron demand Diels−Alder reactions of an unsymmetrical N-acyl-6-amino-1,2,4,5 ...
Dale L. Boger (1306542), Scott E. Wolkenberg (1639027)   +1 more
core   +1 more source

Dramatically Enhanced Reactivity of Fullerenes and Tetrazine towards the Inverse-Electron-Demand Diels-Alder Reaction inside a Porous Porphyrinic Cage

, 2022
Inverse-electron-demand Diels-Alder reaction (IEDDA) between fullerenes and 1,2,4,5-tetrazine generally requires harsh conditions and long reaction times due to their strong electron-accepting nature.
Gunnam, Anilkumar, Xiujun Yu, Ho Ko, Young, Avinash Dhamija, Hwang, In-Chul, In-Chul Hwang, Hochan Lee, Anilkumar Gunnam, Dhamija, Avinash, Kim, Kimoon, Lee, Hochan, Yu, Xiujun, In‐Chul Hwang, Young Ho Ko, Kimoon Kim   +14 more
core   +1 more source

Synthesis of Novel Triazoles, Tetrazine, Thiadiazoles and Their Biological Activities

Molecules, 2015
An expedient synthesis of novel triazoles, tetrazine and thiadiazoles, using conveniently accessible and commercially available starting materials has been achieved.
Mohammed A. Al-Omair, Abdelwahed R. Sayed, Magdy M. Youssef   +2 more
doaj   +1 more source

Tetrazine chelate ligands bridging two [Ru(acac)2] fragments : mixed valency and radical complex formation [PDF]

, 2023
Using bis(3‐methyl‐2‐pyridyl)‐1,2,4,5‐tetrazine 1, 3‐(2‐pyrimidyl)‐6‐methyl‐1,2,4,5‐tetrazine 2 and bis(2‐pyrimidyl)‐1,2,4,5‐tetrazine=bmtz as ligands, the complexes 3=[Ru(acac)2(1)], 4={[Ru(acac)2]2(1)], 5={[Ru(acac)2]2(bmtz)], and 6={[Ru(acac)2]2(2 ...
Filippou, Vasileios, Fiedler, Jan, Ringenberg, Mark R., Schwederski, Brigitte, Kaim, Wolfgang, Löw, Isabell   +5 more
core   +1 more source

Rational design for high bioorthogonal fluorogenicity of tetrazine‐encoded green fluorescent proteins

Natural Sciences, 2022
The development of bioorthogonal fluorogenic probes constitutes a vital force to advance life sciences. Tetrazine‐encoded green fluorescent proteins (GFPs) show high bioorthogonal reaction rate and genetic encodability but suffer from low fluorogenicity.
Longteng Tang, Riley M. Bednar, Nikita D. Rozanov, Marcus L. Hemshorn, Ryan A. Mehl, Chong Fang   +5 more
doaj   +1 more source

Synthesis and properties of a promising high energy and low impact sensitivity explosive: hydroxylammonium 3-hydrazino-6-(1H-1,2,3,4-tetrazol-5-ylimino)-s-tetrazine

FirePhysChem, 2023
Tetrazine compounds, especially their energetic salts, show good application prospect in high-performing energetic materials (EMs). Among them, the hydroxylammonium salt show the best energetic properties.
Zihan Zhang, Xiang Chen, Yuankai Chen, Yuanyuan Li, Hai Nan, Haixia Ma   +5 more
doaj   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Synthesis and Inverse Electron Demand Diels−Alder Reactions of 3,6-Bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine

, 2016
The synthesis of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine (2) and the scope of its reactivity in inverse electron demand Diels−Alder reactions are disclosed representing the first systematic study of the [4 + 2] cycloaddition reactions of 3,6 ...
Dale L. Boger (1306542), Danielle R. Soenen (2728564), Jeffrey M. Zimpleman (2675299)   +2 more
core   +1 more source