Results 11 to 20 of about 7,204 (227)

Tetrazine-Containing Amino Acid for Peptide Modification and Live Cell Labeling. [PDF]

PLoS ONE, 2015
A novel amino acid derivative 3-(4-(1, 2, 4, 5-tetrazine-3-yl) phenyl)-2-aminopropanoic acid was synthesized in this study. The compound possessed better water-solubility and was synthesized more easily compared with the well-known and commercially ...
Zhongqiu Ni, Lanxia Zhou, Xu Li, Jing Zhang, Shouliang Dong   +4 more
doaj   +2 more sources

Development of a 11C-labeled tetrazine for rapid tetrazine–trans-cyclooctene ligation

Chemical Communications, 2013
Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest.
Herth, Matthias Manfred, Andersen, Valdemar L., Lehel, Szabolcs, Madsen, Jacob, Knudsen, Gitte Moos, Kristensen, Jesper Langgaard   +5 more
openaire   +4 more sources

Site-Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids. [PDF]

Angew Chem Int Ed Engl
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Sarkar R, Joshi M, Chatterjee A.
europepmc   +3 more sources

Fluorescent Liquid Tetrazines [PDF]

Molecules, 2021
Tetrazines with branched alkoxy substituents are liquids at ambient temperature that despite the high chromophore density retain the bright orange fluorescence that is characteristic of this exceptional fluorophore. Here, we study the photophysical properties of a series of alkoxy-tetrazines in solution and as neat liquids.
Maximilian Paradiz Dominguez, Begüm Demirkurt, Marion Grzelka, Daniel Bonn, Laurent Galmiche, Pierre Audebert, Albert M. Brouwer   +6 more
openaire   +5 more sources

Synthesis, Characterization, and Cycloaddition Reactivity of a Monocyclic Aromatic 1,2,3,5-Tetrazine

, 2019
Herein we disclose the synthesis and full characterization of the first monocyclic aromatic 1,2,3,5-tetrazine, 4,6-diphenyl-1,2,3,5-tetrazine. Initial studies of its cycloaddition reactivity, mode, regioselectivity, and scope illustrate that it ...
Zhi-Chen Wu (5613515), Dale L. Boger (1306542), Zhi-Chen Wu, Dale L. Boger   +3 more
core   +4 more sources

Redox Potential Tuning of s-Tetrazine by Substitution of Electron-Withdrawing/Donating Groups for Organic Electrode Materials

Molecules, 2021
Herein, we tune the redox potential of 3,6-diphenyl-1,2,4,5-tetrazine (DPT) by introducing various electron-donating/withdrawing groups (methoxy, t-butyl, H, F, and trifluoromethyl) into its two peripheral benzene rings for use as electrode material in a
Dong Joo Min, Kyunam Lee, Hyunji Park, Ji Eon Kwon, Soo Young Park   +4 more
doaj   +1 more source

The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

Frontiers in Nuclear Medicine, 2022
Alzheimer's disease (AD) is the most common neurodegenerative disease, with an increasing prevalence. Currently, there is no ideal diagnostic molecular imaging agent for diagnosing AD.
Sara Lopes van den Broek, Dag Sehlin, Jens V. Andersen, Blanca I. Aldana, Natalie Beschörner, Maiken Nedergaard, Gitte M. Knudsen, Gitte M. Knudsen, Stina Syvänen, Matthias M. Herth, Matthias M. Herth   +10 more
doaj   +1 more source

Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers

Pharmaceutics, 2022
Several gastrin-releasing peptide receptor (GRPR) antagonists with improved in vivo behavior have been recently developed and tested in the clinic. However, despite the generally mild side effects of peptide receptor radionuclide therapy (PRRT), toxicity
Alice D’Onofrio, Francisco Silva, Lurdes Gano, Paula Raposinho, Célia Fernandes, Arkadiusz Sikora, Monika Wyczółkowska, Renata Mikołajczak, Piotr Garnuszek, António Paulo   +9 more
doaj   +1 more source

Recent advances in the synthesis and performance of 1,2,4,5-tetrazine-based energetic materials

FirePhysChem, 2023
In recent years, the development of novel advanced energetic materials has significantly shifted toward nitrogen heterocyclic derivatives, which demonstrate a great potential for multipurpose application patterns.
Leonid L. Fershtat
doaj   +1 more source

Enhanced through-bond energy transfer-based bioorthogonal probe enables catalytic-amplified and sensitive detection of microRNA-21 for clinical lung cancer diagnosis. [PDF]

Smart Mol
Inverse Diels‐Alder Cycloaddition Reaction was developed for ultrasensitive miR‐21 detection. Based on the enhanced Through‐Bond Energy Transfer and catalytic amplification, it shows a detection limit of 3.58 × 10−18 M and 100 aM–100 nM linear range. It enables high‐contrast cell/tissue imaging and distinguishes lung cancer patients in serum, promising
Li Y, Han F, Huang H, Zhou D, Long S, Sun W, Du J, Fan J, Ning J, Peng C, Peng X.   +10 more
europepmc   +2 more sources