Results 11 to 20 of about 9,278 (213)
Small-Molecule Activation of mRNA Translation by Click-to-Release Reaction in Cells. [PDF]
Angew Chem Int Ed EnglA new method to control mRNA activity using bioorthogonal click‐to‐release reactions is presented. The 5′ cap is modified with a trans‐cyclooctene (TCO) that quickly reacts with hydroxyaryl‐tetrazines and efficiently releases the native cap 0. TCO‐capped mRNAs are initially translationally inactive but can be activated with non‐toxic, cell‐permeable ...
Vosman T +5 more
europepmc +3 more sources
Fluorescent Liquid Tetrazines [PDF]
Molecules, 2021 Tetrazines with branched alkoxy substituents are liquids at ambient temperature that despite the high chromophore density retain the bright orange fluorescence that is characteristic of this exceptional fluorophore. Here, we study the photophysical properties of a series of alkoxy-tetrazines in solution and as neat liquids.
Maximilian Paradiz Dominguez +6 more
openaire +6 more sources
Recent advances in the synthesis and performance of 1,2,4,5-tetrazine-based energetic materials
FirePhysChem, 2023 In recent years, the development of novel advanced energetic materials has significantly shifted toward nitrogen heterocyclic derivatives, which demonstrate a great potential for multipurpose application patterns.
Leonid L. Fershtat
doaj +1 more source
Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation [PDF]
, 2020 An inverse electron demand Diels–Alder reaction between tetrazine and trans-cyclooctene (TCO) holds great promise for protein modification and manipulation.
Chudasama, V. +6 more
core +1 more source
Frontiers in Nuclear Medicine, 2022 Alzheimer's disease (AD) is the most common neurodegenerative disease, with an increasing prevalence. Currently, there is no ideal diagnostic molecular imaging agent for diagnosing AD.
Sara Lopes van den Broek +10 more
doaj +1 more source
Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers
Pharmaceutics, 2022 Several gastrin-releasing peptide receptor (GRPR) antagonists with improved in vivo behavior have been recently developed and tested in the clinic. However, despite the generally mild side effects of peptide receptor radionuclide therapy (PRRT), toxicity
Alice D’Onofrio +9 more
doaj +1 more source
Tetrazine bioorthogonal chemistry derived in vivo imaging
Frontiers in Molecular Biosciences, 2022 Bioorthogonal chemistry represents plenty of highly efficient and biocompatible reactions that proceed selectively and rapidly in biological situations without unexpected side reactions towards miscellaneous endogenous functional groups.
Gaoxiang Zhao +9 more
doaj +1 more source
Tetrazine‐Responsive Self‐immolative Linkers [PDF]
ChemBioChem, 2016 AbstractMolecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled
Neumann, Kevin +6 more
openaire +4 more sources
Pharmaceuticals, 2022 Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels–Alder (IEDDA) reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) represents an attractive strategy for molecular imaging via antibodies.
Christoph Bredack +4 more
doaj +1 more source
ACS Central Science, 2016 Marrying bioorthogonal drug activation to hydrogel localization makes doxorubicin treatment more potent, more tolerable in work by Mejia Oneto et al.
R. David Row, Jennifer A. Prescher
doaj +4 more sources