Systematic screening of different polyglycerin‐based dienophile macromonomers for efficient nanogel formation through IEDDA inverse nanoprecipitation [PDF]
, 2019 Alternatives for strain‐promoted azide–alkyne cycloaddition (SPAAC) chemistries are needed because of the employment of expensive and not easily scalable precursors such as bicyclo[6.1.0]non‐4‐yne (BCN).
Haag, Rainer +2 more
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Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]
, 2019 The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B +3 more
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Overview of Syntheses and Molecular-Design Strategies for Tetrazine-Based Fluorogenic Probes
Molecules, 2021 Various bioorthogonal chemistries have been used for fluorescent imaging owing to the advantageous reactions they employ. Recent advances in bioorthogonal chemistry have revolutionized labeling strategies for fluorescence imaging, with inverse electron ...
Sang-Kee Choi, Jonghoon Kim, Eunha Kim
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Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions [PDF]
, 2012 In this article we present a fast and efficient methodology for biochemical surface patterning under extremely mild conditions. Micropatterned azide/benzaldoxime-surfaces were prepared by microcontact printing of a heterobifunctional cyclooctyne oxime ...
Arlinghaus, Heinrich F +6 more
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Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. [PDF]
, 2018 Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge ...
Gervay-Hague, Jacquelyn +2 more
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A Decade of Bioorthogonal Chemistry [PDF]
Accounts of Chemical Research, 2011 Inventing new chemical reactions is a long-standing passion of chemists, as reflected in the ever-popular field of reaction methodology. Historically, the environment in which newly crafted transformations would be performed imposed minimal limitations on reaction design; after all, solvents can be screened to find an optimal choice, temperature can be
openaire +2 more sources
Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology
Molecules, 2013 Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments.
Xiu Zhang, Yan Zhang
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Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups. [PDF]
, 2020 In vivo compatible reactions have a broad range of possible applications in chemical biology and the pharmaceutical sciences. Here we report tetrazines that can be removed by exposure to isonitriles under very mild conditions.
Eckvahl, Hannah J +7 more
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Site-selective protein-modification chemistry for basic biology and drug development. [PDF]
, 2015 Nature has produced intricate machinery to covalently diversify the structure of proteins after their synthesis in the ribosome. In an attempt to mimic nature, chemists have developed a large set of reactions that enable post-expression modification of ...
A Perols +78 more
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Spreading of a mycobacterial cell-surface lipid into host epithelial membranes promotes infectivity
eLife, 2020 Several virulence lipids populate the outer cell wall of pathogenic mycobacteria. Phthiocerol dimycocerosate (PDIM), one of the most abundant outer membrane lipids, plays important roles in both defending against host antimicrobial programs and in ...
CJ Cambier +3 more
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