Results 61 to 70 of about 11,629 (239)

Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation

Angewandte Chemie, EarlyView.
CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova, Manisha B. Walunj, Claudia Höbartner   +2 more
wiley   +2 more sources

Cyclooctyne-based reagents for uncatalyzed click chemistry: A computational survey [PDF]

, 2009
With the goal of identifying alkyne-like reagents for use in click chemistry, but without Cu catalysts, we used B3LYP density function theory (DFT) to investigate the trends in activation barriers for the 1,3-dipolar cycloadditions of azides with various
Chenoweth, David, Chenoweth, Kimberly, Goddard, William A. III   +2 more
core   +1 more source

CXCR4-targeted and MMP-responsive iron oxide nanoparticles for enhanced magnetic resonance imaging [PDF]

, 2014
MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity and the commonly administered contrast agents lack specificity.
Aboagye, EO, Gallo, J, Kamaly, N, Lavdas, I, Long, NJ, Nguyen, Q, Stevens, E, Wylezinska-Arridge, M   +7 more
core   +1 more source

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, EarlyView.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source

Covalent Network Formation Rate Controls Depletion‐Induced Supramolecular Assembly in Hybrid Double Network Hydrogels

Angewandte Chemie, EarlyView.
Tuning the rate of covalent network formation in hybrid double network hydrogels regulates whether supramolecular filaments retain their low‐nm structures or depletion‐induced supramolecular assembly takes place forming bundles. This kinetic handle programs the mesoscale architecture and toughness of the hydrogels, establishing a link between ...
Mertcan Özel, Sebastian Novosedlik, Tingxian Liu, Lucía López‐Gandul, Heleen Duijs, Hari Veera Prasad Thelu, Ciqing Tong, Roxanne E. Kieltyka   +7 more
wiley   +2 more sources

Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes [PDF]

, 2019
In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the ...
Deary, Michael, Kozhevnikov, Valery N., Mantso, Theodora, Panayiotidis, Mihalis I., Sims, Mark T.   +4 more
core   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Controlled Orientation of Active Sites in a Nanostructured Multienzyme Complex [PDF]

, 2016
Multistep cascade reactions in nature maximize reaction efficiency by co-assembling related enzymes. Such organization facilitates the processing of intermediates by downstream enzymes.
A Sachdeva, A Weckbecker, BM Hutchins, CC Roberts, CH Kim, CJ Delebecque, D Guan, DE Torres Pazmino, EM Brustad, H Choe, H Nanba, H Pettersson, HS Seo, J Fu, J Fu, J-L Lin, JA Johnson, JE Dueber, JW Chin, M Castellana, M Leibundgut, M Slatner, MG Hoesl, MH Seo, MJ Lajoie, ML Blackman, NJ Agard, O Idan, P Bauler, P Brunker, P Bubner, R Narayanaswamy, RJ Conrado, S An, S Schoffelen, SI Lim, SI Lim, SI Lim, SI Lim, SR Bond, TM Schmeing, TS Moon, Y Kim, Y Zhang   +43 more
core   +5 more sources

Bionanomaterials from plant viruses [PDF]

, 2015
Plant virus capsids have emerged as useful biotemplates for material synthesis. All plant virus capsids are assembled with high-precision, three-dimensional structures providing nanoscale architectures that are highly monodisperse, can be produced in ...
Aljabali, Alaa A. A., Evans, David
core   +2 more sources

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source