Results 81 to 90 of about 11,629 (239)

Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase

Angewandte Chemie, EarlyView.
Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology

Advanced Science
Bioorthogonal catalysis has revolutionized the field of chemical biology by enabling selective and controlled chemical transformations within living systems.
Yan Zhang, Qizhen Huang, Fang Lei, Wanlong Qian, Chengfeng Zhang, Qi Wang, Chaoqun Liu, Haiwei Ji, Faming Wang   +8 more
doaj   +1 more source

Cancer's sweet spot: techniques to harness saccharides in tumor biology

BioTechniques
All of the cells in our bodies are enveloped in sugar, this sweet coating plays a particularly interesting and crucial role in tumor biology. Here, we review the techniques being used to detect and exploit cancer's sweet spot.
Jade Parker
doaj   +1 more source

Bioorthogonal Modification of the Major Sheath Protein of Bacteriophage M13: Extending the Versatility of Bionanomaterial Scaffolds [PDF]

, 2016
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Biconjugate Chemistry, copyright © American Chemical Society after peer review.
Daub, Elisabeth, Honek, John, Urquhart, Taylor   +2 more
core   +2 more sources

Bioorthogonal Engineered Virus-Like Nanoparticles for Efficient Gene Therapy

Nano-Micro Letters, 2023
Highlights A virus-like nanoparticle (reBiosome) was developed via site-specific codon mutation for displaying unnatural amino acid (Azi) on virus envelope protein at a rational site, followed by conjugating weak acid-responsive polyethylene glycol ...
Chun-Jie Bao, Jia-Lun Duan, Ying Xie, Xin-Ping Feng, Wei Cui, Song-Yue Chen, Pei-Shan Li, Yi-Xuan Liu, Jin-Ling Wang, Gui-Ling Wang, Wan-Liang Lu   +10 more
doaj   +1 more source

Facile, productive, and cost-effective synthesis of a novel tetrazine-based iron oxide nanoparticle for targeted image contrast agents and nanomedicines [PDF]

, 2018
We have developed an operationally simple, time, and cost-effective protocol to produce a novel tetrazine-based iron oxide nanoparticle using commercially available and inexpensive materials.
A Kuzmin, AG Kolhatkar, Alexandru Chivu, AM Morawski, BL Oliveira, CS McKay, DMM Jaradat, F Herranz, HL Evans, JB Haun, JM Baskin, JR Dunetz, Juan C. Kaski, M Colombo, M Ohgushi, Marco M. Meloni, MF Debets, MM Meloni, NK Devaraj, RA Trivedi, SA Schmitz, SK Mishra, Stephen Barton, Taigang He, Wenhui Song   +24 more
core   +3 more sources

Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry

Journal of the American Chemical Society, 2012
Mycobacteria, including the pathogen Mycobacterium tuberculosis, use the non-mammalian disaccharide trehalose as a precursor for essential cell-wall glycolipids and other metabolites. Here we describe a strategy for exploiting trehalose metabolic pathways to label glycolipids in mycobacteria with azide-modified trehalose (TreAz) analogues.
Swarts, Benjamin M, Holsclaw, Cynthia M, Jewett, John C, Alber, Marina, Fox, Douglas M, Siegrist, M Sloan, Leary, Julie A, Kalscheuer, Rainer, Bertozzi, Carolyn R   +8 more
openaire   +4 more sources

Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA

Angewandte Chemie, EarlyView.
Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Isomeric triazines exhibit unique profiles of bioorthogonal reactivity. [PDF]

, 2019
Expanding the scope of bioorthogonal reactivity requires access to new and mutually compatible reagents. We report here that 1,2,4-triazines can be tuned to exhibit unique reaction profiles with biocompatible strained alkenes and alkynes.
Briggs, Jeffrey S, Houk, KN, Kamber, David N, Liang, Yong, Liu, Fang, Long, Zane G, Nguyen, Sean S, Prescher, Jennifer A, Row, R David, Shih, Hui-Wen   +9 more
core  

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

Chemistry & Biology, 2014
The selective chemical modification of biological molecules drives a good portion of modern drug development and fundamental biological research. While a few early examples of reactions that engage amine and thiol groups on proteins helped establish the value of such processes, the development of reactions that avoid most biological molecules so as to ...
McKay, Craig S., Finn, M.G.
openaire   +2 more sources