Results 91 to 100 of about 2,778,442 (233)

Ein Ruthenium(CAAC‐5)‐Olefin‐Metathese‐Katalysator für die Biokonjugation

Angewandte Chemie, EarlyView.
Die Instabilität von Rutheniumkatalysatoren in wässrigen Lösungen schränkt die Olefinmetathese in biologischen Medien ein. Es wird über einen Ru(CAAC‐5)‐Komplex berichtet, der unter biologisch relevanten Bedingungen aktiv bleibt und die Biokonjugation mit Proteinen, Peptiden und einem künstlichen Metalloenzym ermöglicht.
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

Fluorogenic and Bioorthogonal Modification of RNA Using Photoclick Chemistry

Biomolecules, 2020
A bromoaryltetrazole-modified uridine was synthesized as a new RNA building block for bioorthogonal, light-activated and postsynthetic modification with commercially available fluorescent dyes.
Katja Krell, Hans-Achim Wagenknecht
doaj   +1 more source

Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications

Frontiers in Chemistry, 2015
Bioorthogonal chemistry has recently emerged to be one of the most powerful tools in drug discovery and chemical biology. The exploration of it has successfully advanced the field of natural product research.
Xuejun eZhu, Wenjun eZhang
doaj   +1 more source

Preparation of tetrazine-containing [2 + 1] complexes of ^99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels–Alder chemistry

, 2017
A new 99mTc-labelled tetrazine for targeted imaging using bioorthogonal chemistry was developed and evaluated in vivo using a trans-cyclooctene derived bisphosphonate targeting regions of high bone turnover and bone lesions.
Shannon Czorny, Robert G. Ungard, Tanya Miladinovic, Gurmit Singh, Abdolreza Yazdani, John F. Valliant, Nancy Janzen   +6 more
core   +1 more source

Click‐Spaltung quartärer Anilinium‐Tetrazine ermöglicht Kaskadenaufbau multifunktioneller biomolekularer Gerüste

Angewandte Chemie, EarlyView.
Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

Bioorthogonal “Click” Cycloadditions: A Toolkit for Modulating Polymers and Nanostructures in Living Systems

Reactions
“Click” cycloadditions offer effective pathways for the modifications of supramolecular structures, polymers, and nanomaterials. These reactions include bioorthogonal mechanisms that do not interfere with the biological processes, providing a type of ...
Irene Lepori, Yavuz Oz, Jungkyun Im, Nandan Ghosh, Mohuya Paul, Ulrich S. Schubert, Stefano Fedeli   +6 more
doaj   +1 more source

Bioorthogonal Reactions in Animals

, 2020
International audienceAbstract The advent of bioorthogonal chemistry has led to the development of powerful chemical tools that enable increasingly ambitious applications.
Rémi Châtre, Sébastien Papot, Taran, Frédéric, Davide Audisio, Papot, Sébastien, Porte, Karine, Riberaud, Maxime, Châtre, Rémi, Audisio, Davide, Maxime Riberaud, Frédéric Taran, Karine Porte   +11 more
core   +1 more source

T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy

Advanced Science, 2019
Due to specific immune recognition receptors on the surface of T cells, their membranes are promising mimic nanocarriers for delivering drugs to tumor lesions.
Yutong Han, Hong Pan, Wenjun Li, Ze Chen, Aiqing Ma, Ting Yin, Ruijing Liang, Fuming Chen, Yifan Ma, Yan Jin, Mingbin Zheng, Baohong Li, Lintao Cai   +12 more
doaj   +1 more source

Click-ready iridium(iii) complexes as versatile bioimaging probes for bioorthogonal metabolic labeling† [PDF]

RSC Chemical Biology
Herein, we report the synthesis, photophysical characterization and validation of iridium(iii)–polypyridine complexes functionalized for click chemistry and bioorthogonal chemistry, as well as their versatile applications as probes in bioimaging studies ...
Vincent Rigolot, Clémence Simon, Aude Bouchet, Lucas Lancel, Veronica Di Battista, Dmitry Karpov, Boris Vauzeilles, Corentin Spriet, Michel Sliwa, Sylvain Bohic, Christophe Biot, Cédric Lion   +11 more
doaj   +1 more source

Leveraging Bioorthogonal Chemistry for Hyperpolarized Magnetic Resonance and Metal Uncaging

, 2018
Bioorthogonal chemistry is a burgeoning area of study that has innumerable applications. This dissertation describes applications of bioorthogonal chemistry to solve problems in the fields of imaging and metal uncaging.
Bae, Junu Tyle
core