Results 111 to 120 of about 2,778,442 (233)
Computational organic chemistry has become a valuable tool in the field of bioorthogonal chemistry, offering insights and aiding in the progression of this branch of chemistry.
Svatunek, Dennis; orcid:
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Bioorthogonal Click Chemistry-Based Synthetic Cell Glue
, 2018 Artificial methods of cell adhesion can be effective in building functional cell complexes in vitro, but methods for in vivo use are currently lacking. Here, a chemical cell glue based on bioorthogonal click chemistry with high stability and robustness ...
Hahn, SK +11 more
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Bioorthogonal Chemistry in Biology and Medicine
Journal of Molecular and Genetic Medicine, 2018 Bioorthogonal chemistry and reactions developed from innovations in chemistry, having their excellent biocompatibility can be applied in various biological reactions. As these reactions, does not interfere with other reactions in the biological system, they can be used as excellent tools for tracking and studying dynamics of various biological ...
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Angewandte Chemie International Edition, EarlyView.Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt +9 more
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Non-specific cysteine modifications on proteins induced by trans-cyclooctene [PDF]
RSC Chemical BiologyTetrazine-trans-cyclooctene (Tz-TCO) click chemistry has been widely adopted for various applications due to its faster reaction kinetics and higher biocompatibility compared to conventional copper-catalyzed click chemistry. However, most click chemistry
Zhijian Yan, Wei Qin
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BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Specific Pathogen Detection Using Bioorthogonal Chemistry and Diagnostic Magnetic Resonance
, 2019 The development of faster and more sensitive detection methods capable of identifying specific bacterial species and strains has remained a longstanding clinical challenge.
Liong, Monty +9 more
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Chemistry – A European Journal, EarlyView.Self‐assembled photocatalyst Ru(Ada‐bpy)(bpy)2⊂HACD targets cancer cells and catalyzes the prodrug to drug upon exposure to visible light, providing spatially and temporally control in cancer cells. This strategy achieves efficient, controllable, and targeted activation of prodrugs within cancer cells, laying the foundation of effectively reducing the ...
Jianghua Liu +3 more
wiley +1 more source
Development of Blue‐to‐Near‐Infrared rTCO–Caged Fluorogenic Probes for Click‐to‐Release Monitoring
Chemistry – A European Journal, EarlyView.A series of fluorogenic rTCO‐caged click‐to‐release probes was prepared and evaluated both in a cuvette and in live cells. Some of the probes exhibited significant turn‐on and efficient fluorophore release spanning the blue‐to‐NIR region. A significant difference in the performance of the compounds in live cells was observed, highlighting the need for ...
Marek Chovanec +4 more
wiley +1 more source
Photocatalysis‐Triggered Click Reactions and Applications
European Journal of Organic Chemistry, EarlyView.Photoclick chemistry offers broad applications ranging from materials science to bioconjugation, with precise spatiotemporal control over click reactions. Initially limited to UV activation, recent advances have extended photoclick processes to the visible and NIR regions thanks to the photocatalysis.
Margaux Walter +2 more
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