Results 121 to 130 of about 2,778,442 (233)

Live Organoid Cyclic Imaging

Advanced Science
Organoids are becoming increasingly relevant in biology and medicine for their physiological complexity and accuracy in modeling human disease. To fully assess their biological profile while preserving their spatial information, spatiotemporal imaging ...
David E. Reynolds, Yusha Sun, Xin Wang, Phoebe Vallapureddy, Jianhua Lim, Menghan Pan, Andres Fernandez Del Castillo, Jonathan C. T. Carlson, Mark A. Sellmyer, MacLean Nasrallah, Zev Binder, Donald M. O'Rourke, Guo‐li Ming, Hongjun Song, Jina Ko   +14 more
doaj   +1 more source

Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells

Exploration, EarlyView.
Engineered micro/nanomaterials enable high‐efficiency CTC capture, release, and multimodal molecular profiling. Integrated with AI‐driven analytics, these platforms decode tumor heterogeneity and metastatic dynamics, advancing real‐time monitoring and precision oncology through DNA, RNA, and protein cross‐scale data fusion.
Hao Li, Jiaojiao Sun, Kunguo Liu, Shijie Wang, Bowen Fu, Hong Zhu, Peng Cao, Xin Han   +7 more
wiley   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Iontronic click-to-release enables electrically controlled delivery of drugs and biomolecules beyond charge and size limitations

Nature Communications
Dynamic and programmable control of therapeutic delivery is a long-standing goal in medicine. Iontronic devices offer precise electronic control over the dosage of bioactive molecules, yet their use has been confined to charged, low-molecular-weight ...
Sebastian Hecko, Marle E. J. Vleugels, Christian Bayer, Donghak Byun, Moa E. Hörberg, Nikolaus Poremba, Rassen Boukraa, Patrick Keppel, Andreas Löffler, Walter Kuba, Helena Saarela Unemo, Iwona Bernacka-Wojcik, Theresia Arbring Sjöström, Magnus Berggren, Daniel T. Simon, Rainer Schindl, Linda Waldherr, Hannes Mikula, Johannes Bintinger   +18 more
doaj   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Bioorthogonal photocatalytic proximity labeling in primary living samples

Nature Communications
In situ profiling of subcellular proteomics in primary living systems, such as native tissues or clinic samples, is crucial for understanding life processes and diseases, yet challenging due to methodological obstacles.
Ziqi Liu, Fuhu Guo, Yufan Zhu, Shengnan Qin, Yuchen Hou, Haotian Guo, Feng Lin, Peng R. Chen, Xinyuan Fan   +8 more
doaj   +1 more source

Construction optimization and functional applications of fluorescent nanodiamonds

Responsive Materials, EarlyView.
This review summarizes synthesis, surface modification and optical properties of fluorescent nanodiamonds. Their advances in quantum sensing, single‐photon emission and biomedicine are discussed, and existing challenges and future directions are presented.
Yunpeng Yang, Sen Zhang, Chao Chen, Wensi Yang, Zuanquan Chen, Rui Fan, Linlin Liu, Benjian Liu, Kang Liu, Zhibo Zhang, Bing Dai, Jiaqi Zhu   +11 more
wiley   +1 more source

TADF‐Active Tetrazole Luminophores for Visible‐Light Functionalization of Nanoparticles and Surfaces

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
A series of tetrazoles are reported that undergo 1,3‐dipolar cycloadditions with alkene and alkyne substrates, generating (dihydro)pyrazole products that exhibit thermally activated delayed fluorescence (TADF). The “photo‐click” reactivity of these tetrazoles is leveraged to functionalize nanoparticles and surfaces with TADF‐active chromophores ...
Ryoga Hojo, Katrina Bergmann, Siyuan L. Xie, Connor S. Durfy, William L. Primrose, Athan T. Gogoulis, Seja A. Elgadi, Mitchell J. Demchuk, Thomas Kalab, Peiqi Hu, Eva M. Nichols, Zachary M. Hudson   +11 more
wiley   +2 more sources

Bioorthogonal Reagents: Design, Synthesis, and Reactivity

, 2023
The development of reactions that fit the stringent criteria for click chemistry and bioorthogonal chemistry has enabled discoveries and applications in fields ranging from materials science to chemical biology.
Abularrage, Nile S.
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