Development of Bioorthogonal Chemistry and Its Applications [PDF]
openThis thesis traces the evolution of bioorthogonal chemistry from its conceptual origins to its pubblic recognition by the Nobel Prize. The journey begins with Sharpless's click chemistry paradigm, which established criteria for ideal reactions ...
LIAO, WILLIAMS
core
Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology
European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau +3 more
wiley +1 more source
Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes
, 2018 Krüger T, Weiland S, Falck G, et al. Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes. Angewandte Chemie International Edition.
Müller, Kristian ; https://orcid.org/ +17 more
core +1 more source
Exploring Lignification Complexity in Plant Cell Walls with Airyscan Super-resolution Microscopy and Bioorthogonal Chemistry. [PDF]
Chem Biomed Imaging, 2023 Simon C +8 more
europepmc +1 more source
Cleavable Micelles Through Bioorthogonal Chemistry
, 2023 Very recently, our team has discovered a click and release reaction involving iminosydnones, a family of mesoionic compounds and cyclooctynes. This bioorthogonal reaction operates in a two-step process: a [3+2] cycloaddition followed by a retro Diels-Alder, which generates two new compounds, a click product and a release product.
openaire +1 more source
Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers. [PDF]
Pharmaceutics, 2022 D'Onofrio A +9 more
europepmc +1 more source
Manipulating complex chromatin folding via CRISPR-guided bioorthogonal chemistry. [PDF]
Proc Natl Acad Sci U S A, 2022 Qin G, Yang J, Zhao C, Ren J, Qu X.
europepmc +1 more source
Chemical biology tools take the strain: Bioorthogonal chemistry
Bioorthogonal chemistry has become a mainstay technique used by chemists and biologists alike. Here we look back at one of its key reactions: strain-promoted azide–alkyne cycloadditions (SPAAC).
Tanaka, Katsunori, Vong, Kenward
core +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.Cysteine–fluorophore conjugates were efficiently prepared through a visible‐light‐driven thiol–ene approach employing solely organic photocatalysts. The reaction proceeds under mild, metal‐free conditions. The fluorophore scope includes mono‐ and dialkene‐functionalized naphthalene, naphthalimide, and aromatic diimide derivatives.
Julieth Bellaizac‐Riascos +4 more
wiley +1 more source
Thiomethyltetrazines Are Reversible Covalent Cysteine Warheads Whose Dynamic Behavior can be "Switched Off" via Bioorthogonal Chemistry Inside Live Cells. [PDF]
J Am Chem Soc, 2023 Tallon AM +4 more
europepmc +1 more source