Results 161 to 170 of about 2,778,442 (233)

Abiotic Chemistry in Living Animals: Therapeutic Applications

International audienceThe concept of click chemistry, first reported in 2001, has paved the way for bioorthogonal chemistry, which represents a class of chemical transformations that operate in biological media without interfering with endogenous ...
Taran, Frédéric, Papot, Sébastien, Porte, Karine, Thoreau, Fabien   +3 more
core   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, Volume 13, Issue 59, 23 October 2026.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

Dual fluorescent labeling of GLP-1R in live cells via enzymatic tagging and bioorthogonal chemistry. [PDF]

RSC Chem Biol, 2022
Lewandowski TM, An P, Ramil CP, Fang M, Lin Q.   +4 more
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Bioorthogonal chemistry for deciphering lipid biology in living systems. [PDF]

RSC Chem Biol
Portasany B, Souto-Trinei FA, Brea RJ.
europepmc   +1 more source

In Situ Self‐Assembled Molecular Fortifying Agent for Enhanced Retention and Therapeutic Efficacy of Radiopharmaceuticals

Aggregate, Volume 7, Issue 10, October 2026.
A molecular‐fortifying agent strategy based on in situ self‐assembly is developed to prolong tumor retention of radioligands. After tumor‐targeting, FAP‐α cleavage triggers nanofiber formation, presenting azide anchors for bioorthogonal capture of pre‐accumulated radioligands.
Daojia Liu, Xiaoqin Luo, Xiaojuan Wang, Xing Liu, Fanglei Zhang, Pan Wang, Jibin Song, Junqiang Chen   +7 more
wiley   +1 more source

Target identification and occupancy measurement of necrosis avid agent rhein using bioorthogonal chemistry-enabling probes. [PDF]

RSC Adv, 2022
Jiang C, Zhang J, Hu S, Gao M, Zhang D, Yao N, Jin Q.   +6 more
europepmc   +1 more source

An All-in-One Bioorthogonal System for Precise Cancer Therapy

Bioorthogonal chemistry exhibits great potential in drug design and synthesis. However, the usage of two components (prodrug and trigger) is still an urgent conundrum, which are separated from each other and then delivered to the organism individually ...
Yue Wei (407499), Xiaogang Qu (19674), Jinsong Ren (260913), Lu Zhang (50563), Si Wu (154794), Tingting Cui (564531)   +5 more
core   +1 more source

Fluorogenic Sydnones for Bioorthogonal Labeling of DNA

Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.
Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller, Hans‐Achim Wagenknecht   +1 more
wiley   +1 more source