Results 101 to 110 of about 2,778,442 (233)
Bioorthogonal Chemistries for Glycoprofiling and Beyond
The FASEB Journal, 2012 The glycome is dynamically regulated during development and disease progression. The ability to detect changes in protein glycosylation, in tissue and serum samples as well as in vivo, is of considerable interest for biomarker identification and disease monitoring.
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Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy
Angewandte Chemie International Edition, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
In‐Gel Generated Palladium Nanostructures as Bioorthogonal Uncaging Reactors
Advanced NanoBiomed ResearchIn the quest to alleviate the severe side effects of chemotherapy, a promising approach is through prodrugs, an inactivate form of the drug that is administered systemically but activated locally.
Aisling McGuigan +4 more
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A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation
Angewandte Chemie International Edition, EarlyView.The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf +4 more
wiley +1 more source
Bioorthogonal chemistry : new perspective for organic chemistry [PDF]
, 2018 This work is about bioorthogonal chemistry as a chemistry of reactions taking place in the living, in particular human, organism environment. In the search for reactions that can occur under conditions, the focus is mainly on the reactions of molecules ...
Miszczak, K.
core
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein–Protein Conjugates [PDF]
Bioorthogonal chemistry holds great potential to generate difficult-to-access protein–protein conjugate architectures. Current applications are hampered by challenging protein expression systems, slow conjugation chemistry, use of undesirable catalysts ...
Deweid, Lukas +11 more
core +1 more source
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates [PDF]
, 2019 A highly efficient technology for protein functionalization with commonly used bioorthogonal motifs for Diels-Alder cycloaddition with inverse electron demand (DAinv).
Laura, Neises +11 more
core +2 more sources
Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation
Chemistry & Biology, 2014 The selective chemical modification of biological molecules drives a good portion of modern drug development and fundamental biological research. While a few early examples of reactions that engage amine and thiol groups on proteins helped establish the value of such processes, the development of reactions that avoid most biological molecules so as to ...
McKay, Craig S., Finn, M.G.
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Bioorthogonal Janus microparticles for photothermal and chemo‐therapy
Smart MedicineBioorthogonal chemistry, recognized as a highly efficient tool in chemical biology, has shown significant value in cancer treatment. The primary objective is to develop efficient delivery strategies to achieve enhanced bioorthogonal drug treatment for ...
Qingfei Zhang +4 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2019 Many biophysical techniques that are available to study the structure, function and dynamics of cellular constituents require modification of the target molecules.
Leonhard Jakob +2 more
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