Results 21 to 30 of about 1,698 (209)
Click Chemistry in Human Cancer Research
Zhongliu Fangzhi YanjiuAs one of the typical bioorthogonal chemistry reactions, click chemistry joins molecules similar to “Lego”. Bioorthogonal click chemistry is used to modify cancer cells, design antitumor drugs, delivery drugs, manipulate immune cells, and help ...
Baihong ZHANG, Hongyun YUE
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Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers
Pharmaceutics, 2022 An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight ...
Mario Saletti +12 more
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Click chemistry for 3D bioprinting [PDF]
Materials Horizons, 2023 Bioinks are employed in the fabrication of 3D scaffolds containing cells and macromolecules that can be applied in regenerative medicine.
Lei Nie +5 more
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Click Chemistry in Peptide-Based Drug Design
Molecules, 2013 Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly
Irwin Chaiken, Rachna Aneja, Huiyuan Li
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Click chemistry in the design of AIEgens for biosensing and bioimaging
Aggregate, 2023 The development of rapid, selective, and sensitive fluorescent sensors is essential for visualizing and quantifying biological molecules and processes in vitro, ex vitro, and in vivo, which is important for not only fundamental biological studies but the
Marie‐Claire Giel, Yuning Hong
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Click Chemistry in Proteomic Investigations [PDF]
Cell, 2020 Despite advances in genetic and proteomic techniques, a complete portrait of the proteome and its complement of dynamic interactions and modifications remains a lofty, and as of yet, unrealized, objective. Specifically, traditional biological and analytical approaches have not been able to address key questions relating to the interactions of proteins ...
Christopher G. Parker, Matthew R. Pratt
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, 2019 Click chemistry has found wide application in bioconjugation, enabling control over the site of modification in biomolecules. Demonstrations of this chemistry to construct chemically defined antibody-drug conjugates (ADCs) have increased in recent years, following studies that support benefits of homogeneity and site-specificity of drug placement on ...
Tak Ian, Chio, Susan L, Bane
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Polysaccharides: The “Click” Chemistry Impact [PDF]
Polymers, 2011 Polysaccharides are complex but essential compounds utilized in many areas such as biomaterials, drug delivery, cosmetics, food chemistry or renewable energy. Modifications and functionalizations of such polymers are often necessary to achieve molecular structures of interest.
Elchinger, Pierre-Henri +6 more
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Recent Advances in Transition Metal-Catalyzed Ring-Opening Reaction of Aziridine
CompoundsThe smallest strained, saturated N-heterocycles, such as aziridine, can be a valuable building block in synthetic organic chemistry. Ring-opening reactions with various nucleophiles could be the most important strategy to synthesize various value-added ...
Partha Sarathi Bera +3 more
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