Results 41 to 50 of about 2,703,843 (291)
, 2019 Click chemistry has found wide application in bioconjugation, enabling control over the site of modification in biomolecules. Demonstrations of this chemistry to construct chemically defined antibody-drug conjugates (ADCs) have increased in recent years, following studies that support benefits of homogeneity and site-specificity of drug placement on ...
Tak Ian, Chio, Susan L, Bane
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A simple access to transition metal cyclopropenylidene complexes [PDF]
, 2015 The authors gratefully acknowledge the Royal Society (University Research Fellowship to CSJC) and the DOE (DE-FG02-13ER16370) for financial support.We report the first example of BAC–Cu complex (BAC = bis(diisopropylamino)cyclopropenylidene) and its use ...
Slawin, Alexandra MZ +12 more
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Advances in Green and Sustainable Photo Redox Catalysis for Organic Transformation
Innovation of Chemistry & Materials for SustainabilityAdvances in visible-light-mediated photo redox catalysis have created an exceptional approach for small-molecule activation and new chemical bond formation in organic synthesis. This is an alternative technique to generate new reactive intermediates and
Yafia Kousin Mirza +3 more
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Nanoplasmonics tuned “click chemistry” [PDF]
Nanoscale, 2016 Nanoplasmonics is a growing field of optical condensed matter science dedicated to optical phenomena at the nanoscale level in metal systems. Extensive research on noble metallic nanoparticles (NPs) has emerged within the last two decades due to their ability to keep the optical energy concentrated in the vicinity of NPs, in particular, the ability to ...
Tijunelyte, I. +6 more
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Recent updates in click and computational chemistry for drug discovery and development [PDF]
, 2023 Drug discovery is a costly and time-consuming process with a very high failure rate. Recently, click chemistry and computer-aided drug design (CADD) represent popular areas for new drug development.
Cai, Jiang Hong +6 more
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Click-Chemistry Cross-Linking of Hyaluronan Graft Copolymers
Pharmaceutics, 2022 An easy and viable crosslinking procedure by click-chemistry (click-crosslinking) of hyaluronic acid (HA) was developed. In particular, the clickable propargyl groups of hyaluronane-based HA-FA-Pg graft copolymers showing low and medium molecular weight ...
Mario Saletti +12 more
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Click Chemistry and Radiochemistry: An Update
Bioconjugate Chemistry, 2023 The term "click chemistry" describes a class of organic transformations that were developed to make chemical synthesis simpler and easier, in essence allowing chemists to combine molecular subunits as if they were puzzle pieces. Over the last 25 years, the click chemistry toolbox has swelled from the canonical copper-catalyzed azide-alkyne ...
David Bauer +4 more
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, 2021 Engineering of carbohydrate-active enzymes such as glycosynthases to enable chemoenzymatic synthesis of bespoke oligosaccharides has been limited by the lack of suitable ultrahigh-throughput screening methods capable of robustly detecting either starting
Ayushi Agrawal +11 more
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Click Chemistry in Peptide-Based Drug Design
Molecules, 2013 Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly
Irwin Chaiken, Rachna Aneja, Huiyuan Li
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Click chemistry in the design of AIEgens for biosensing and bioimaging
Aggregate, 2023 The development of rapid, selective, and sensitive fluorescent sensors is essential for visualizing and quantifying biological molecules and processes in vitro, ex vitro, and in vivo, which is important for not only fundamental biological studies but the
Marie‐Claire Giel, Yuning Hong
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