Results 41 to 50 of about 319,759 (300)

Recent Advances in Transition Metal-Catalyzed Ring-Opening Reaction of Aziridine

Compounds
The smallest strained, saturated N-heterocycles, such as aziridine, can be a valuable building block in synthetic organic chemistry. Ring-opening reactions with various nucleophiles could be the most important strategy to synthesize various value-added ...
Partha Sarathi Bera, Yafia Kousin Mirza, Tarunika Sachdeva, Milan Bera   +3 more
doaj   +1 more source

Comparative Analysis of Click Chemistry Mediated Activity-Based Protein Profiling in Cell Lysates

Molecules, 2013
Activity-based protein profiling uses chemical probes that covalently attach to active enzyme targets. Probes with conventional tags have disadvantages, such as limited cell permeability or steric hindrance around the reactive group.
Yinliang Yang, Xiaomeng Yang, Steven H. L. Verhelst   +2 more
doaj   +1 more source

Surface modification of UV Cured epoxy resins by click Chemistry

, 2010
A novel method for surface modification of UV-cured epoxy network was described. Photoinitiated cationic copolymerization of a bisepoxide, namely 3,4-epoxy cyclohexylmethyl 3,4-epoxycyclohexanecarboxylate (EEC) with epibromohydrine (EBH) by using a ...
Abadie, Adamson, Ak, Boey, Chandran, Chen, Collman, Dag, Decker, Decker, Decker, Dufour, Durmaz, Erbil, Ergin, Gacal, Gacal, Gao, Haensch, Haensch, Haensch, Karagoz, Kim, Kiskan, Kolb, Kukut, Li, Lummerstorfer, Lutz, Nagai, Nakajima, Opsteen, Parrish, Ranjan, Rengifo, Sangermano, Sangermano, Schlegel, Sun, Takimoto, Tasdelen, Tornoe, Tsarevsky, Tsarevsky, Wang, Yagci, Yagci, Yagci   +47 more
core   +1 more source

Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. [PDF]

, 2018
Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge ...
Gervay-Hague, Jacquelyn, Hsieh, Hsiao-Wu, Park, Simon S   +2 more
core   +1 more source

Polysaccharides: The “Click” Chemistry Impact [PDF]

Polymers, 2011
Polysaccharides are complex but essential compounds utilized in many areas such as biomaterials, drug delivery, cosmetics, food chemistry or renewable energy. Modifications and functionalizations of such polymers are often necessary to achieve molecular structures of interest.
Elchinger, Pierre-Henri, Faugeras, Pierre-Antoine, Boëns, Benjamin, Brouillette, François, Montplaisir, Daniel, Zerrouki, Rachida, Lucas, Romain   +6 more
openaire   +2 more sources

Molecular Hybridization of Alkaloids Using 1,2,3-Triazole-Based Click Chemistry

Molecules, 2023
Alkaloids found in multiple species, known as ‘driver species’, are more likely to be included in early-stage drug development due to their high biodiversity compared to rare alkaloids.
Devan Buchanan, Ashley M. Pham, Sandeep K. Singh, Siva S. Panda   +3 more
doaj   +1 more source

Innovative Peptide Bioconjugation Chemistry with Radionuclides: Beyond Classical Click Chemistry

Pharmaceuticals
Background: The incorporation of radionuclides into peptides and larger biomolecules requires efficient and sometimes biorthogonal reaction conditions, to which click chemistry provides a convenient approach.
Samantha Leier, Frank Wuest
doaj   +1 more source

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. [PDF]

, 2015
Although recent methods for the engineering of antibody-drug conjugates (ADCs) have gone some way to addressing the challenging issues of ADC construction, significant hurdles still remain.
Caddick, S, Chester, KA, Chudasama, V, Maruani, A, Miranda, E, Smith, ME   +5 more
core   +1 more source

Introduction: Click Chemistry [PDF]

Chemical Reviews, 2021
Neal K. Devaraj, M. G. Finn
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source