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Application of click chemistry in nanoparticle modification and its targeted delivery
Background Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparticle research is a representative ...
Gawon Yi +4 more
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Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications
This short review describes the assistance of click chemistry in the chemical modification of glycosaminoglycans. Through an alkyne-azide 1,3-dipolar cycloaddition reaction, the chemically and physiologically stable triazole unit connects ...
Smritilekha Bera, Dhananjoy Mondal
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Click chemistry for 3D bioprinting [PDF]
Bioinks are employed in the fabrication of 3D scaffolds containing cells and macromolecules that can be applied in regenerative medicine.
Lei Nie +5 more
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Click chemistry has found wide application in bioconjugation, enabling control over the site of modification in biomolecules. Demonstrations of this chemistry to construct chemically defined antibody-drug conjugates (ADCs) have increased in recent years, following studies that support benefits of homogeneity and site-specificity of drug placement on ...
Tak Ian, Chio, Susan L, Bane
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Harnessing Sulfur(VI) Fluoride Exchange Click Chemistry and Photocatalysis for Deaminative Benzylic Arylation [PDF]
While among the most common functional handles present in organic molecules, amines are a widely underutilized linchpin for C–C bond formation. To facilitate C–N bond cleavage, large activating groups are typically used but result in the generation of ...
Akin, Aydogan +5 more
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Advances in Green and Sustainable Photo Redox Catalysis for Organic Transformation
Advances in visible-light-mediated photo redox catalysis have created an exceptional approach for small-molecule activation and new chemical bond formation in organic synthesis. This is an alternative technique to generate new reactive intermediates and
Yafia Kousin Mirza +3 more
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Nanoplasmonics tuned “click chemistry” [PDF]
Nanoplasmonics is a growing field of optical condensed matter science dedicated to optical phenomena at the nanoscale level in metal systems. Extensive research on noble metallic nanoparticles (NPs) has emerged within the last two decades due to their ability to keep the optical energy concentrated in the vicinity of NPs, in particular, the ability to ...
Tijunelyte, I. +6 more
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Click Chemistry and Radiochemistry: An Update
The term "click chemistry" describes a class of organic transformations that were developed to make chemical synthesis simpler and easier, in essence allowing chemists to combine molecular subunits as if they were puzzle pieces. Over the last 25 years, the click chemistry toolbox has swelled from the canonical copper-catalyzed azide-alkyne ...
David Bauer +4 more
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Recent Advances in Transition Metal-Catalyzed Ring-Opening Reaction of Aziridine
The smallest strained, saturated N-heterocycles, such as aziridine, can be a valuable building block in synthetic organic chemistry. Ring-opening reactions with various nucleophiles could be the most important strategy to synthesize various value-added ...
Partha Sarathi Bera +3 more
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Polysaccharides: The “Click” Chemistry Impact [PDF]
Polysaccharides are complex but essential compounds utilized in many areas such as biomaterials, drug delivery, cosmetics, food chemistry or renewable energy. Modifications and functionalizations of such polymers are often necessary to achieve molecular structures of interest.
Elchinger, Pierre-Henri +6 more
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