Results 51 to 60 of about 319,759 (300)

Cymantrene–Triazole "Click" Products: Structural Characterization and Electrochemical Properties [PDF]

, 2014
We report the first known examples of triazole-derivatized cymantrene complexes (η5-[4-substituted triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I), obtained via a “click” chemical synthesis, bearing a phenyl, 3-aminophenyl, or 4-aminophenyl moiety ...
Abboud J.-L. M., Anderson C. B., Astruc D., Badèche S., Baltz T., Beyer B., Bock V. D., Borissova A. O., Calladine J. A., Carvalho I., Chong D., Clough M. C., Dallagi T., David P. Day, David. L. Hughes, Dietmar Steverding, Evrard D., Geiger W. E., Geiger W. E., Gil M. V., Glans L., Gregory G. Wildgoose, Gritzner G., Happ B., Hirano T., Hirumi H., Holovics T. C., Huber W., Huisgen R., Jaschinski T., Kee J. W., Kilpin K. J., Kolb H. C., Kolb H. C., Lage M. L., Lawrence E. J., Laws D. R., Laws D. R., Leroux Y. R., Leroux Y. R., Liu Y., Lunquist R. T., Ornelas C., Ornelas C., Otón F., Otón F., Rapakousiou A., Romero T., Romero T., Romero T., Schweinfurth D., Schweinfurth D., Schweinfurth D., Sheridan M. V., Steverding D., Sünkel K., Thomas Dann, To T. T., Vasily S. Oganesyan, Yoo E. J.   +59 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Immunological Techniques to Assess Protein Thiol Redox State: Opportunities, Challenges and Solutions

Antioxidants, 2020
To understand oxidative stress, antioxidant defense, and redox signaling in health and disease it is essential to assess protein thiol redox state. Protein thiol redox state is seldom assessed immunologically because of the inability to distinguish ...
James Nathan Cobley, Holger Husi
doaj   +1 more source

Extended π-conjugated pyrene derivatives: structural, photophysical and electrochemical properties [PDF]

, 2016
This article presents a set of extended π-conjugated pyrene derivatives, namely 1,3-di(arylethynyl)-7-tert-butylpyrenes, which were synthesized by a Pd-catalyzed Sonogashira coupling reaction of 1,3-dibromo-7-tert-butylpyrenes with the corresponding ...
Bordeau, Chen, Cheng, Cheng, Chercka, Crawford, Crosby, Diring, Droumaguet, Duong, Feng, Feng, Feng, Figueira-Duarte, Han, Hu, Hu, Hu, Ito, Jeon, Karmakar, Karthik, Kim, Kim, Lee, Lee, Li, Mardanya, Mardanya, Murphy, Palatinus, Pietrangelo, Sakuda, Salunke, Sato, Sheldrick, Sung, Tang, Usta, Wang, Wang, Wu, Zhao   +42 more
core   +2 more sources

Click chemistry for 3D bioprinting

Materials Horizons, 2023
Bioinks are employed in the fabrication of 3D scaffolds containing cells and macromolecules that can be applied in regenerative medicine.
Lei Nie, Yanfang Sun, Oseweuba Valentine Okoro, Yaling Deng, Guohua Jiang, Amin Shavandi   +5 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Cyclooctyne-based reagents for uncatalyzed click chemistry: A computational survey [PDF]

, 2009
With the goal of identifying alkyne-like reagents for use in click chemistry, but without Cu catalysts, we used B3LYP density function theory (DFT) to investigate the trends in activation barriers for the 1,3-dipolar cycloadditions of azides with various
Chenoweth, David, Chenoweth, Kimberly, Goddard, William A. III   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology

Molecules, 2013
Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments.
Xiu Zhang, Yan Zhang
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source