Results 41 to 50 of about 29,994 (285)

Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues

Molecules, 2021
A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragments are attached via polymethylene linkers to both nitrogen atoms of the heterocycle moiety (uracil, 6-methyluracil, thymine, quinazoline-2,4-dione ...
Olga V. Andreeva, Bulat F. Garifullin, Vladimir V. Zarubaev, Alexander V. Slita, Iana L. Yesaulkova, Alexandrina S. Volobueva, Mayya G. Belenok, Maria A. Man’kova, Liliya F. Saifina, Marina M. Shulaeva, Alexandra D. Voloshina, Anna P. Lyubina, Vyacheslav E. Semenov, Vladimir E. Kataev   +13 more
doaj   +1 more source

Influence of the Weak Nuclear Force on Metal-Promoted Autocatalytic Strecker Synthesis of Amino Acids: Formation of a Chiral Pool of Precursors for Prebiotic Peptide and Protein Synthesis

Life, 2023
Natural chiral amino acids typically adopt an L structural configuration. While a preference for specific molecular chiralities is observed throughout biology and cellular chemistry, the origins of this preference are unclear.
J. A. Cowan
doaj   +1 more source

Influenza A virus preferentially snatches noncoding RNA caps

, 2016
Influenza A virus (IAV) lacks the enzyme for adding 5' caps to its RNAs and snatches the 5' ends of host capped RNAs to prime transcription. Neither the preference of the host RNA sequences snatched nor the effect of cap-snatching on host processes is ...
Li, Ruidong, Trombly, Melanie I., Dai, Weiwei, Gu, Weifeng, Mello, Craig C., Gammon, Don B., Wang, Jennifer P., Gallagher, Glen R., Liu, Ping, Finberg, Robert W.   +9 more
core   +1 more source

Cap-independent translation of plant viral RNAs [PDF]

Virus Research, 2006
The RNAs of many plant viruses lack a 5' cap and must be translated by a cap-independent mechanism. Here, we discuss the remarkably diverse cap-independent translation elements that have been identified in members of the Potyviridae, Luteoviridae, and Tombusviridae families, and genus Tobamovirus.
Elizabeth L Pettit, Kneller, Aurélie M, Rakotondrafara, W Allen, Miller   +2 more
openaire   +2 more sources

Development of Allosteric Ribozymes for ATP and l-Histidine Based on the R3C Ligase Ribozyme

Life
During the evolution of the RNA, short RNAs are thought to have joined together to form long RNAs, enhancing their function as ribozymes. Previously, the artificial R3C ligase ribozyme (73 nucleotides) was successfully reduced to 46 nucleotides; however,
Yuna Akatsu, Hiromi Mutsuro-Aoki, Koji Tamura   +2 more
doaj   +1 more source

Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase

Viruses, 2021
The ongoing COVID-19 pandemic exemplifies the general need to better understand viral infections. The positive single-strand RNA genome of its causative agent, the SARS coronavirus 2 (SARS-CoV-2), encodes all viral enzymes.
Roberto Benoni, Petra Krafcikova, Marek R. Baranowski, Joanna Kowalska, Evzen Boura, Hana Cahová   +5 more
doaj   +1 more source

Practical Synthesis of Cap‐4 RNA

ChemBioChem, 2019
AbstractEukaryotic mRNAs possess 5′ caps that are determinants for their function. A structural characteristic of 5′ caps is methylation, with this feature already present in early eukaryotes such as Trypanosoma. While the common cap‐0 (m7GpppN) shows a rather simple methylation pattern, the Trypanosoma cap‐4 displays seven distinguished additional ...
Josef Leiter, Dennis Reichert, Andrea Rentmeister, Ronald Micura   +3 more
openaire   +2 more sources

Lethal Mutagenesis of RNA Viruses and Approved Drugs with Antiviral Mutagenic Activity

Viruses, 2022
In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of mutagens, driving viral populations to extinction.
Ikbel Hadj Hassine, Manel Ben M’hadheb, Luis Menéndez-Arias   +2 more
doaj   +1 more source

A systems-level mass spectrometry-based technique for accurate and sensitive quantification of the RNA cap epitranscriptome

, 2023
Chemical modifications of transcripts with a 5′ cap occur in all organisms and function in many aspects of RNA metabolism. To facilitate analysis of RNA caps, we developed a systems-level mass spectrometry-based technique, CapQuant, for accurate and ...
Xin-Yuan Fu, Lai, Yong, Timothy K. Lu, Lin, Zhenguo, Lu, Timothy K., Zhenguo Lin, Yu Liu, Shi, Pei Yong, Yong Lai, Samie R. Jaffrey, Chew, Bing Liang Alvin, Jin Wang, Dong, Hongping, Luang Xu, Xu, Luang, Hongping Dong, Liu, Yu, Dedon, Peter C., Pei-Yong Shi, Fu, Xin Yuan, Peter C. Dedon, Bing Liang Alvin Chew, Luo, Dahai, Jaffrey, Samie R., Wang, Jin, Dahai Luo   +25 more
core   +1 more source

Stereoselective Phosphorylation of d-Ribose as a Driver of Life’s Homochirality

Life
Life demonstrates remarkable homochirality of its major building blocks: nucleic acids, amino acids, sugars, and phospholipids. Phospholipid bilayer vesicles (liposomes) are formed at the water/air interface from Langmuir layers and contain ribose, a ...
Vladimir M. Subbotin, Gennady Fiksel
doaj   +1 more source