Results 81 to 90 of about 4,295,333 (324)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Country ownership and sustainable programming of the HIV response in South Africa: A scoping review

Southern African Journal of HIV Medicine, 2023
Background: Concerns have arisen regarding the extent to which South Africa’s HIV response can be country-owned and sustainable given substantial foreign investment and technical support. Objectives: To assess the extent to which South Africa’s national
Refilwe N. Phaswana-Mafuya, Edith Phalane, Haley Sisel, Lifutso Motsieloa, Katherine Journeay, Vuyiseka Dubula, Jabulile Sibeko, Pholokgolo Ramothwala   +7 more
doaj   +1 more source

Capability Lifecycle

, 2016
The capability lifecycle is a framework that extends the resource-based view by articulating patterns and paths in the evolution of organizational capabilities. The lifecycle describes the development of a capability from founding to maturity, as well as subsequent branching into additional stages, and explains the sources of heterogeneity in ...
Zuzul, T, Helfat, C
openaire   +1 more source

All-optical spiking neurosynaptic networks with self-learning capabilities [PDF]

Nature, 2019
Software implementations of brain-inspired computing underlie many important computational tasks, from image processing to speech recognition, artificial intelligence and deep learning applications.
J. Feldmann, N. Youngblood, C. Wright, H. Bhaskaran, Wolfram H. P. Pernice   +4 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

*Entrepreneurship and Dynamic Capabilities: A Review, Model and Research Agenda

, 2006
The emergent literature on dynamic capabilities and their role in value creation is riddled with inconsistencies, overlapping definitions, and outright contradictions.
S. Zahra, H. Sapienza, P. Davidsson
semanticscholar   +1 more source

Developing people capabilities for the promotion of sustainability in facility management practices [PDF]

, 2015
Sustainability is becoming an integral part of the life-cycle development of built facilities. It is increasingly highlighted during the post construction phase, as facility management personnel can have major influence to the sustainability agenda
Sarpin, Norliana
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Pushing the limit of instrument capabilities

, 2010
Chemically Peculiar (CP) stars have been subject of systematic research since more than 50 years. With the discovery of pulsation of some of the cool CP stars, the availability of advanced spectropolarimetric instrumentation and high signal- to-noise ...
Alexander F. Kholtygin, Denis V. Shulyak, Gautier Mathys, Khan, Khan, Khokhlova, Kholtygin, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kochukhov, Kurtz, Lanz, Laurent Eyer, Mary, Mikulášek, North, Oleg Kochukhov, Pickering, Pierre North, Przybilla, Ryabchikova, Ryabchikova, Ryabchikova, Ryabchikova, Ryabchikova, Sergey N. Fabrika, Shulyak, Shulyak, Shulyak, Shulyak, Tatyana E. Burlakova, Werner W. Weiss, Woszczyk   +35 more
core   +1 more source