Results 81 to 90 of about 759,638 (266)
Complexity synchronization analysis of neurophysiological data: Theory and methods
Frontiers in Network PhysiologyIntroductionWe present a theoretical foundation based on the spontaneous self-organized temporal criticality (SOTC) and multifractal dimensionality μ to model complex neurophysiological and behavioral systems to infer the optimal empirical transfer of ...
Ioannis Schizas +10 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Correlation of MRI Biomarkers with Tumor Necrosis in Hras5 Tumor Xenograft in Athymic Rats
Neoplasia: An International Journal for Oncology Research, 2007 Magnetic resonance imaging (MRI) can measure the effects of therapies targeting the tumor vasculature and has demonstrated that vascular-damaging agents (VDA) induce acute vascular shutdown in tumors in human and animal models. However, at subtherapeutic
Daniel P. Bradley +6 more
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The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Epilepsia Open, 2019 Objective Our objective was to evaluate the protective efficacy of the neurosteroid pregnanolone (3α‐hydroxy‐5β pregnan‐20‐one), a GABAA receptor‐positive allosteric modulator, as an adjunct to benzodiazepine therapy against the chemical warfare nerve ...
Lucille Lumley +7 more
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Community Psychology in Global Perspective, 2019 The present article first presents a critique about the current status of the CMH field; and second based in theoretical and empirical literature it presents a perspective inspired by the inception of community psychology, namely the empowerment and ...
José Ornelas +3 more
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PRIMDEx: Prototyping rapid innovation of microfluidics devices for experimentation
SLAS TechnologyMicrofluidics has quickly become an established technology in the transformative fields that make up broader biotechnology. Microfluidics has applications spanning the entire breadth of the discipline, from chemical synthesis, environmental monitoring ...
Patrick B. Kruk, Jose A. Wippold
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Complexity synchronization in emergent intelligence
Scientific ReportsIn this work, we use a simple multi-agent-based-model (MABM) of a social network, implementing selfish algorithm (SA) agents, to create an adaptive environment and show, using a modified diffusion entropy analysis (DEA), that the mutual-adaptive ...
Korosh Mahmoodi +5 more
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