Results 131 to 140 of about 3,349,066 (314)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
This paper offers a critique of Martha Nussbaum’s description of the capability approach, and offers an alternative. I will argue that Nussbaum’s characterization of the capability approach is flawed, in two ways.
Robeyns, Ingrid
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Desirability to characterize process capability [PDF]
Over the past few years continuously new process capability indices have been developed, most of them with the aim to add some feature missed in former process capability indices.
Jessenberger, J., Weihs, Claus
core
Bandpass filter design with spurious frequency reduction capability [PDF]
, 2014 Passband microstrip coupled line filter are widely used in daily microwave engineering practice. There are various topologies to implement microstrip bandpass filters such as end-coupled, parallel coupled, hairpin, interdigital and combine filters.
Muda @ Ali, Rosnani
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Cold solid propellant motor has stop-restart capability [PDF]
, 1966 Solid propellant rocket is kept and fired at low temperatures in launch vehicles or spacecraft. The motor is capable of developing a specific impulse comparable to that of liquid propellant motors, is started, stopped, and restarted, and is stored in ...
Hendel, F. J.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Multidimensional reaction kinetic ablation program /REKAP/ [PDF]
, 1967 Multidimensional reaction kinetics ablation program provides an improved capability for analyzing thermal performance of partially penetrated charring ablator heat shields. The capability was provided for determining transient temperature histories in an
Aston, B., Binck, E., Collingswood, B.
core +1 more source