Results 151 to 160 of about 1,404,975 (316)
Capability Modeling: Initial Experiences
Enterprises operate in dynamically changing environments, consequently, information systems (IS) are a subject to continuous changes. The IS need to be adjusted to different customers, markets and run-time contexts affecting their design and delivery ...
Grabis, Jānis +6 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Valuing the Environment in a Diverse World
, 2011 What challenge does the diversity of values – when we are dealing with the environment – pose? More specifically, can the capability approach – given its claim to accommodate widespread cultural differences – take on board the different ways in which we ...
Watene, Krushil
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Organizational Flexibility and Performance: Case Study of ARAK Industrial Estate Manufacturing Organizations [PDF]
مطالعات مدیریت بهبود و تحول, 2010 Rapid changes and the dynamics of competitive markets now more than ever necessitate the urge to achieve flexibility in organizations. Flexibility is not a spontaneous phenomenon, so organizations shouldidentify the factors generating flexibility and ...
doaj
The capability approach to intergenerational justice: A survey [PDF]
The politically influential idea of sustainable development is closely tied to the concept of inter- and intragenerational justice without clarifying these concepts and their relationship.
Leßmann, Ortrud +3 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Dynamic capability and superior firm performance in the UK Media Industry [PDF]
, 2013 The past decade has seen a transformation in the way television broadcasters have managed their businesses. This paper examines the ‘dynamic capability’ of two UK television broadcasters, BskyB and ITV, and their ability to adapt and transform themselves
Oliver, John, Oliver, John James
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source